Characterization of fibronectin attachment by a human transitional cell carcinoma line, T24

D. E. Coplen, E. J. Brown, J. McGarr, T. L. Ratliff

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The ability of transitional cell carcinoma cells to adhere to and invade the extracellular matrix is important in invasion and metastasis. The glycoprotein fibronectin is associated with laminin and Type IV collagen in the bladder basement membrane. We characterized the interaction between T-24 cells, a cell line derived from an invasive transitional cell tumor, and fibronectin. The cells use the α5β1 heterodimeric integrin receptor complex to mediate adherence via the classical (RGDS) fibronectin binding site. The importance of the α5β1 receptor to T-24 function is unknown and under investigation.

Original languageEnglish
Pages (from-to)1312-1315
Number of pages4
JournalJournal of Urology
Volume145
Issue number6
DOIs
StatePublished - 1991

Keywords

  • Bladder
  • Transitional cell carcinoma

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