Characterization of digital waveforms using thermodynamic analogs: Detection of contrast-targeted tissue in vivo

Michael S. Hughes, Jon N. Marsh, Hyuing Zhang, Adam K. Woodson, John S. Allen, Elizabeth K. Lacy, Cordelia Carradine, Gregory M. Lanza, Samuel A. Wickline

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We describe characterization of backscatter from tumor tissue targeted with a nanoparticle-based ultrasound contrast agent in vivo using analogs of thermodynamic quantities. We apply these waveform characteristics to detection of tumor neovasculature in tumors implanted in athymic nude mice, which were imaged using a research ultrasound scanner over a 2-hour period after injection of α v β 3-targeted perfluorocarbon nanoparticles. Images were constructed from backscattered ultrasound using two different approaches: fundamental B-mode imaging and a signal receiver based on a thermodynamic analog (H C). The study shows that the thermodynamic analog is capable of detecting differences in backscattered signals that are not apparent with the B-mode approach.

Original languageEnglish
Article number1678189
Pages (from-to)1609-1616
Number of pages8
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume53
Issue number9
DOIs
StatePublished - Sep 2006

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