Characterization of digital waveforms using thermodynamic analogs: Detection of contrast targeted tissue in MDA 435 tumors implanted in athymic mice

M. Hughes, J. N. Marsh, A. K. Woodson, E. K. Lacey, C. Carradine, G. M. Lanza, S. A. Wickline

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations

Abstract

We describe characterization of backscatter from tumor tissue targeted with a nanoparticle-based ultrasound contrast agent in vivo using analogs of thermodynamic quantities. We apply these waveform characteristics to detection of tumor neovasculature in MDA 435 tumors implanted in athymic nude mice, which were imaged using a research ultrasound scanner over a two hour period after injection of αvβ3-targeted perfluorocarbon nanoparticles. Images were constructed from backscattered ultrasound using two different signal receivers: Conventional and a thermodynamic analog (H c). The study shows that the thermodynamic analog is capable of detecting differences in backscattered signals that are invisible to the conventional approach.

Original languageEnglish
Title of host publication2005 IEEE Ultrasonics Symposium
Pages373-376
Number of pages4
DOIs
StatePublished - Dec 1 2005
Event2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands
Duration: Sep 18 2005Sep 21 2005

Publication series

NameProceedings - IEEE Ultrasonics Symposium
Volume1
ISSN (Print)1051-0117

Conference

Conference2005 IEEE Ultrasonics Symposium
CountryNetherlands
CityRotterdam
Period09/18/0509/21/05

Keywords

  • Information-theoretic detector
  • Molecular imaging
  • Nanopartilce contrast agent

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    Hughes, M., Marsh, J. N., Woodson, A. K., Lacey, E. K., Carradine, C., Lanza, G. M., & Wickline, S. A. (2005). Characterization of digital waveforms using thermodynamic analogs: Detection of contrast targeted tissue in MDA 435 tumors implanted in athymic mice. In 2005 IEEE Ultrasonics Symposium (pp. 373-376). [1602872] (Proceedings - IEEE Ultrasonics Symposium; Vol. 1). https://doi.org/10.1109/ULTSYM.2005.1602872