Characterization of Cellular Immune Responses in Thai Individuals with and Without HIV-Associated Neurocognitive Disorders

Silvia Ratto-Kim; Alexandra Schuetz; Pasiri Sithinamsuwan; John Barber; Nicholas Hutchings; Sukalaya Lerdlum; James L.K. Fletcher; Yuwadee Phuang-Ngern; Weerawan Chuenarom; Somporn Tipsuk; Mantana Pothisri; Tanate Jadwattanakul; Supunnee Jirajariyavej; Chayada Sajjaweerawan; Siriwat Akapirat; Thep Chalermchai; Duanghathai Suttichom; Boot Kaewboon; Peeriya Prueksakaew; Putthachard Karnsomlap; David Clifford; Robert H. Paul; Mark S. De Souza; Jerome H. Kim; Jintanat Ananworanich; Victor Valcour

doi:10.1089/aid.2017.0237

Characterization of Cellular Immune Responses in Thai Individuals with and Without HIV-Associated Neurocognitive Disorders

Silvia Ratto-Kim
, Alexandra Schuetz
, Pasiri Sithinamsuwan
, John Barber
, Nicholas Hutchings
, Sukalaya Lerdlum
, James L.K. Fletcher
, Yuwadee Phuang-Ngern
, Weerawan Chuenarom
, Somporn Tipsuk
, Mantana Pothisri
, Tanate Jadwattanakul
, Supunnee Jirajariyavej
, Chayada Sajjaweerawan
, Siriwat Akapirat
, Thep Chalermchai
, Duanghathai Suttichom
, Boot Kaewboon
, Peeriya Prueksakaew
, Putthachard Karnsomlap

David Clifford, Robert H. Paul, Mark S. De Souza, Jerome H. Kim, Jintanat Ananworanich, Victor Valcour

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

HIV-Associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8 ⁺ T cell activation (HLA-DR ⁺ /CD38 ⁺ ) and HIV-specific CD8 ⁺ T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8 ⁺ T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b ⁺ ) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8 ⁺ T cells in the mechanism of HAND development.

Original language	English
Pages (from-to)	685-689
Number of pages	5
Journal	AIDS research and human retroviruses
Volume	34
Issue number	8
DOIs	https://doi.org/10.1089/aid.2017.0237
State	Published - Aug 1 2018

Keywords

CD8+ T cell activation
HIV-Associated neurocognitive disorders
HIV-specific cytolytic T cells

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10.1089/aid.2017.0237

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Ratto-Kim, S., Schuetz, A., Sithinamsuwan, P., Barber, J., Hutchings, N., Lerdlum, S., Fletcher, J. L. K., Phuang-Ngern, Y., Chuenarom, W., Tipsuk, S., Pothisri, M., Jadwattanakul, T., Jirajariyavej, S., Sajjaweerawan, C., Akapirat, S., Chalermchai, T., Suttichom, D., Kaewboon, B., Prueksakaew, P., ... Valcour, V. (2018). Characterization of Cellular Immune Responses in Thai Individuals with and Without HIV-Associated Neurocognitive Disorders. AIDS research and human retroviruses, 34(8), 685-689. https://doi.org/10.1089/aid.2017.0237

@article{37c7c26b84604ee989ee70617f0eeed9,

title = "Characterization of Cellular Immune Responses in Thai Individuals with and Without HIV-Associated Neurocognitive Disorders",

abstract = " HIV-Associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8 + T cell activation (HLA-DR + /CD38 + ) and HIV-specific CD8 + T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8 + T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b + ) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8 + T cells in the mechanism of HAND development.",

keywords = "CD8+ T cell activation, HIV-Associated neurocognitive disorders, HIV-specific cytolytic T cells",

author = "Silvia Ratto-Kim and Alexandra Schuetz and Pasiri Sithinamsuwan and John Barber and Nicholas Hutchings and Sukalaya Lerdlum and Fletcher, \{James L.K.\} and Yuwadee Phuang-Ngern and Weerawan Chuenarom and Somporn Tipsuk and Mantana Pothisri and Tanate Jadwattanakul and Supunnee Jirajariyavej and Chayada Sajjaweerawan and Siriwat Akapirat and Thep Chalermchai and Duanghathai Suttichom and Boot Kaewboon and Peeriya Prueksakaew and Putthachard Karnsomlap and David Clifford and Paul, \{Robert H.\} and \{De Souza\}, \{Mark S.\} and Kim, \{Jerome H.\} and Jintanat Ananworanich and Victor Valcour",

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month = aug,

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doi = "10.1089/aid.2017.0237",

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Ratto-Kim, S, Schuetz, A, Sithinamsuwan, P, Barber, J, Hutchings, N, Lerdlum, S, Fletcher, JLK, Phuang-Ngern, Y, Chuenarom, W, Tipsuk, S, Pothisri, M, Jadwattanakul, T, Jirajariyavej, S, Sajjaweerawan, C, Akapirat, S, Chalermchai, T, Suttichom, D, Kaewboon, B, Prueksakaew, P, Karnsomlap, P, Clifford, D, Paul, RH, De Souza, MS, Kim, JH, Ananworanich, J & Valcour, V 2018, 'Characterization of Cellular Immune Responses in Thai Individuals with and Without HIV-Associated Neurocognitive Disorders', AIDS research and human retroviruses, vol. 34, no. 8, pp. 685-689. https://doi.org/10.1089/aid.2017.0237

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AU - Schuetz, Alexandra

AU - Sithinamsuwan, Pasiri

AU - Barber, John

AU - Hutchings, Nicholas

AU - Lerdlum, Sukalaya

AU - Fletcher, James L.K.

AU - Phuang-Ngern, Yuwadee

AU - Chuenarom, Weerawan

AU - Tipsuk, Somporn

AU - Pothisri, Mantana

AU - Jadwattanakul, Tanate

AU - Jirajariyavej, Supunnee

AU - Sajjaweerawan, Chayada

AU - Akapirat, Siriwat

AU - Chalermchai, Thep

AU - Suttichom, Duanghathai

AU - Kaewboon, Boot

AU - Prueksakaew, Peeriya

AU - Karnsomlap, Putthachard

AU - Clifford, David

AU - Paul, Robert H.

AU - De Souza, Mark S.

AU - Kim, Jerome H.

AU - Ananworanich, Jintanat

AU - Valcour, Victor

PY - 2018/8/1

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N2 - HIV-Associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8 + T cell activation (HLA-DR + /CD38 + ) and HIV-specific CD8 + T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8 + T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b + ) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8 + T cells in the mechanism of HAND development.

AB - HIV-Associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8 + T cell activation (HLA-DR + /CD38 + ) and HIV-specific CD8 + T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8 + T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b + ) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8 + T cells in the mechanism of HAND development.

KW - CD8+ T cell activation

KW - HIV-Associated neurocognitive disorders

KW - HIV-specific cytolytic T cells

UR - https://www.scopus.com/pages/publications/85051079910

U2 - 10.1089/aid.2017.0237

DO - 10.1089/aid.2017.0237

M3 - Article

C2 - 29737194

AN - SCOPUS:85051079910

SN - 0889-2229

VL - 34

SP - 685

EP - 689

JO - AIDS research and human retroviruses

JF - AIDS research and human retroviruses

IS - 8

ER -

Characterization of Cellular Immune Responses in Thai Individuals with and Without HIV-Associated Neurocognitive Disorders

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