Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos)

Chao Zhou; Tsung Han Tsai; Hsiang Chieh Lee; Tejas Kirtane; Marisa Figueiredo; Yuankai K. Tao; Osman O. Ahsen; Desmond C. Adler; Joseph M. Schmitt; Qin Huang; James G. Fujimoto; Hiroshi Mashimo

doi:10.1016/j.gie.2012.02.003

Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos)

Chao Zhou, Tsung Han Tsai, Hsiang Chieh Lee, Tejas Kirtane, Marisa Figueiredo, Yuankai K. Tao, Osman O. Ahsen, Desmond C. Adler, Joseph M. Schmitt, Qin Huang, James G. Fujimoto, Hiroshi Mashimo

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Background: Radiofrequency ablation (RFA) is an endoscopic technique used to eradicate Barrett's esophagus (BE). However, such ablation can commonly lead to neosquamous epithelium overlying residual BE glands not visible by conventional endoscopy and may evade detection on random biopsy samples. Objective: To demonstrate the capability of endoscopic 3-dimensional optical coherence tomography (3D-OCT) for the identification and characterization of buried glands before and after RFA therapy. Design: Cross-sectional study. Setting: Single teaching hospital. Patients: Twenty-six male and 1 female white patients with BE undergoing RFA treatment. Interventions: 3D-OCT was performed at the gastroesophageal junction in 18 patients before attaining complete eradication of intestinal metaplasia (pre-CE-IM group) and in 16 patients after CE-IM (post-CE-IM group). Main Outcome Measurements: Prevalence, size, and location of buried glands relative to the squamocolumnar junction. Results: 3D-OCT provided an approximately 30 to 60 times larger field of view compared with jumbo and standard biopsy and sufficient imaging depth for detecting buried glands. Based on 3D-OCT results, buried glands were found in 72% of patients (13/18) in the pre-CE-IM group and 63% of patients (10/16) in the post-CE-IM group. The number (mean [standard deviation]) of buried glands per patient in the post-CE-IM group (7.1 [9.3]) was significantly lower compared with the pre-CE-IM group (34.4 [44.6]; P = .02). The buried gland size (P = .69) and distribution (P = .54) were not significantly different before and after CE-IM. Limitations: A single-center, cross-sectional study comparing patients at different time points in treatment. Lack of 1-to-1 coregistered histology for all OCT data sets obtained in vivo. Conclusion: Buried glands were frequently detected with 3D-OCT near the gastroesophageal junction before and after radiofrequency ablation.

Original language	English
Pages (from-to)	32-40
Number of pages	9
Journal	Gastrointestinal endoscopy
Volume	76
Issue number	1
DOIs	https://doi.org/10.1016/j.gie.2012.02.003
State	Published - Jul 2012

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Zhou, C., Tsai, T. H., Lee, H. C., Kirtane, T., Figueiredo, M., Tao, Y. K., Ahsen, O. O., Adler, D. C., Schmitt, J. M., Huang, Q., Fujimoto, J. G., & Mashimo, H. (2012). Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos). Gastrointestinal endoscopy, 76(1), 32-40. https://doi.org/10.1016/j.gie.2012.02.003

@article{2712070fea894986bffe8a25b89cc3b0,

title = "Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos)",

abstract = "Background: Radiofrequency ablation (RFA) is an endoscopic technique used to eradicate Barrett's esophagus (BE). However, such ablation can commonly lead to neosquamous epithelium overlying residual BE glands not visible by conventional endoscopy and may evade detection on random biopsy samples. Objective: To demonstrate the capability of endoscopic 3-dimensional optical coherence tomography (3D-OCT) for the identification and characterization of buried glands before and after RFA therapy. Design: Cross-sectional study. Setting: Single teaching hospital. Patients: Twenty-six male and 1 female white patients with BE undergoing RFA treatment. Interventions: 3D-OCT was performed at the gastroesophageal junction in 18 patients before attaining complete eradication of intestinal metaplasia (pre-CE-IM group) and in 16 patients after CE-IM (post-CE-IM group). Main Outcome Measurements: Prevalence, size, and location of buried glands relative to the squamocolumnar junction. Results: 3D-OCT provided an approximately 30 to 60 times larger field of view compared with jumbo and standard biopsy and sufficient imaging depth for detecting buried glands. Based on 3D-OCT results, buried glands were found in 72% of patients (13/18) in the pre-CE-IM group and 63% of patients (10/16) in the post-CE-IM group. The number (mean [standard deviation]) of buried glands per patient in the post-CE-IM group (7.1 [9.3]) was significantly lower compared with the pre-CE-IM group (34.4 [44.6]; P = .02). The buried gland size (P = .69) and distribution (P = .54) were not significantly different before and after CE-IM. Limitations: A single-center, cross-sectional study comparing patients at different time points in treatment. Lack of 1-to-1 coregistered histology for all OCT data sets obtained in vivo. Conclusion: Buried glands were frequently detected with 3D-OCT near the gastroesophageal junction before and after radiofrequency ablation.",

author = "Chao Zhou and Tsai, {Tsung Han} and Lee, {Hsiang Chieh} and Tejas Kirtane and Marisa Figueiredo and Tao, {Yuankai K.} and Ahsen, {Osman O.} and Adler, {Desmond C.} and Schmitt, {Joseph M.} and Qin Huang and Fujimoto, {James G.} and Hiroshi Mashimo",

note = "Funding Information: DISCLOSURE: The following author disclosed financial relationships relevant to this publication: Dr. Fujimoto: LightLab Imaging Inc–St. Jude Medical, royalties from intellectual property owned by MIT and licensed to LightLab Imaging Inc; Carl Zeiss Meditec–St. Jude Medical, royalties from intellectual property owned by MIT and licensed to Carl Zeiss Meditec; scientific advisor to and stock options in Optovue, Inc. The other authors disclosed no financial relationships relevant to this publication. The authors acknowledge the facility support from the VA Boston Healthcare System. NIH grants R01-CA75289-15 (J.G.F., H.M.), R44CA101067-06 , R01-HL095717-03 , R01-NS057476-05 , and K99-EB010071-01A1 , Air Force Office of Scientific Research contract FA9550-10-1-0063 (J.G.F.), Medical Free Electron Laser Program contract FA9550-10-1-0551 (J.G.F.), and the MIT/CIMIT Medical Engineering Fellowship . ",

year = "2012",

month = jul,

doi = "10.1016/j.gie.2012.02.003",

language = "English",

volume = "76",

pages = "32--40",

journal = "Gastrointestinal endoscopy",

issn = "0016-5107",

number = "1",

}

Zhou, C, Tsai, TH, Lee, HC, Kirtane, T, Figueiredo, M, Tao, YK, Ahsen, OO, Adler, DC, Schmitt, JM, Huang, Q, Fujimoto, JG & Mashimo, H 2012, 'Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos)', Gastrointestinal endoscopy, vol. 76, no. 1, pp. 32-40. https://doi.org/10.1016/j.gie.2012.02.003

TY - JOUR

T1 - Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos)

AU - Zhou, Chao

AU - Tsai, Tsung Han

AU - Lee, Hsiang Chieh

AU - Kirtane, Tejas

AU - Figueiredo, Marisa

AU - Tao, Yuankai K.

AU - Ahsen, Osman O.

AU - Adler, Desmond C.

AU - Schmitt, Joseph M.

AU - Huang, Qin

AU - Fujimoto, James G.

AU - Mashimo, Hiroshi

N1 - Funding Information: DISCLOSURE: The following author disclosed financial relationships relevant to this publication: Dr. Fujimoto: LightLab Imaging Inc–St. Jude Medical, royalties from intellectual property owned by MIT and licensed to LightLab Imaging Inc; Carl Zeiss Meditec–St. Jude Medical, royalties from intellectual property owned by MIT and licensed to Carl Zeiss Meditec; scientific advisor to and stock options in Optovue, Inc. The other authors disclosed no financial relationships relevant to this publication. The authors acknowledge the facility support from the VA Boston Healthcare System. NIH grants R01-CA75289-15 (J.G.F., H.M.), R44CA101067-06 , R01-HL095717-03 , R01-NS057476-05 , and K99-EB010071-01A1 , Air Force Office of Scientific Research contract FA9550-10-1-0063 (J.G.F.), Medical Free Electron Laser Program contract FA9550-10-1-0551 (J.G.F.), and the MIT/CIMIT Medical Engineering Fellowship .

PY - 2012/7

Y1 - 2012/7

N2 - Background: Radiofrequency ablation (RFA) is an endoscopic technique used to eradicate Barrett's esophagus (BE). However, such ablation can commonly lead to neosquamous epithelium overlying residual BE glands not visible by conventional endoscopy and may evade detection on random biopsy samples. Objective: To demonstrate the capability of endoscopic 3-dimensional optical coherence tomography (3D-OCT) for the identification and characterization of buried glands before and after RFA therapy. Design: Cross-sectional study. Setting: Single teaching hospital. Patients: Twenty-six male and 1 female white patients with BE undergoing RFA treatment. Interventions: 3D-OCT was performed at the gastroesophageal junction in 18 patients before attaining complete eradication of intestinal metaplasia (pre-CE-IM group) and in 16 patients after CE-IM (post-CE-IM group). Main Outcome Measurements: Prevalence, size, and location of buried glands relative to the squamocolumnar junction. Results: 3D-OCT provided an approximately 30 to 60 times larger field of view compared with jumbo and standard biopsy and sufficient imaging depth for detecting buried glands. Based on 3D-OCT results, buried glands were found in 72% of patients (13/18) in the pre-CE-IM group and 63% of patients (10/16) in the post-CE-IM group. The number (mean [standard deviation]) of buried glands per patient in the post-CE-IM group (7.1 [9.3]) was significantly lower compared with the pre-CE-IM group (34.4 [44.6]; P = .02). The buried gland size (P = .69) and distribution (P = .54) were not significantly different before and after CE-IM. Limitations: A single-center, cross-sectional study comparing patients at different time points in treatment. Lack of 1-to-1 coregistered histology for all OCT data sets obtained in vivo. Conclusion: Buried glands were frequently detected with 3D-OCT near the gastroesophageal junction before and after radiofrequency ablation.

AB - Background: Radiofrequency ablation (RFA) is an endoscopic technique used to eradicate Barrett's esophagus (BE). However, such ablation can commonly lead to neosquamous epithelium overlying residual BE glands not visible by conventional endoscopy and may evade detection on random biopsy samples. Objective: To demonstrate the capability of endoscopic 3-dimensional optical coherence tomography (3D-OCT) for the identification and characterization of buried glands before and after RFA therapy. Design: Cross-sectional study. Setting: Single teaching hospital. Patients: Twenty-six male and 1 female white patients with BE undergoing RFA treatment. Interventions: 3D-OCT was performed at the gastroesophageal junction in 18 patients before attaining complete eradication of intestinal metaplasia (pre-CE-IM group) and in 16 patients after CE-IM (post-CE-IM group). Main Outcome Measurements: Prevalence, size, and location of buried glands relative to the squamocolumnar junction. Results: 3D-OCT provided an approximately 30 to 60 times larger field of view compared with jumbo and standard biopsy and sufficient imaging depth for detecting buried glands. Based on 3D-OCT results, buried glands were found in 72% of patients (13/18) in the pre-CE-IM group and 63% of patients (10/16) in the post-CE-IM group. The number (mean [standard deviation]) of buried glands per patient in the post-CE-IM group (7.1 [9.3]) was significantly lower compared with the pre-CE-IM group (34.4 [44.6]; P = .02). The buried gland size (P = .69) and distribution (P = .54) were not significantly different before and after CE-IM. Limitations: A single-center, cross-sectional study comparing patients at different time points in treatment. Lack of 1-to-1 coregistered histology for all OCT data sets obtained in vivo. Conclusion: Buried glands were frequently detected with 3D-OCT near the gastroesophageal junction before and after radiofrequency ablation.

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DO - 10.1016/j.gie.2012.02.003

M3 - Article

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AN - SCOPUS:84862639146

SN - 0016-5107

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EP - 40

JO - Gastrointestinal endoscopy

JF - Gastrointestinal endoscopy

IS - 1

ER -

Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos)

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