Characterization of bone only metastasis patients with respect to tumor subtypes

Amanda Parkes, Katherine Clifton, Aydah Al-Awadhi, Oluchi Oke, Carla L. Warneke, Jennifer K. Litton, Gabriel N. Hortobagyi

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Metastatic breast cancer (MBC) patients with bone only metastasis (BOM) are a unique population with limited characterization. We identified patients followed at MD Anderson Cancer Center from 01/01/1997 to 12/31/2015 for at least 6 months with a BOM diagnosis as first site of metastasis. Tumor subtype (TS) was assessed by initial breast biopsy immunohistochemistry using hormonal receptor (HR) and HER2 status, with four subtypes identified: HR+/HER2−, HR+/HER2+, HR−/HER2−, HR−/HER2+. HR+ was defined as estrogen receptor or progesterone receptor ≥1%. We identified 1445 patients with BOM, 1048 with TS data available. Among these patients, the majority were HR+/HER2− (78%). Median time from breast cancer diagnosis to first bone metastasis was 2.3 years (95% CI 2.1, 2.5) and varied significantly by TS, with longer time to distant disease in HR+/HER2− patients relative to all other TS (p <.0001). Median overall survival (OS) from breast cancer diagnosis was 8.7 years (95% CI 8.0, 9.7) and varied significantly by TS with poorer OS for HR−/HER2− and HR-/HER2+ patients relative to HR+/HER2− TS (p <.0001). The 442 patients with de novo BOM disease, defined as bone metastasis diagnosis within 4 months of breast cancer diagnosis, had significantly shorter OS (p <.0001). Overall, several higher risk BOM subsets were identified in this analysis, most notably HR−/HER2+ and HR−/HER2− TS and de novo BOM patients.

Original languageEnglish
Article number2
Journalnpj Breast Cancer
Volume4
Issue number1
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

Fingerprint Dive into the research topics of 'Characterization of bone only metastasis patients with respect to tumor subtypes'. Together they form a unique fingerprint.

  • Cite this

    Parkes, A., Clifton, K., Al-Awadhi, A., Oke, O., Warneke, C. L., Litton, J. K., & Hortobagyi, G. N. (2018). Characterization of bone only metastasis patients with respect to tumor subtypes. npj Breast Cancer, 4(1), [2]. https://doi.org/10.1038/s41523-018-0054-x