Characterization of Biomarkers of Hemostasis and Bleeding-Related Outcomes in Children with Cirrhosis

Chaowapong Jarasvaraparn, Courtney Rusch, Michelle Nadler, Julie Drobish, Janis Stoll, Maria Bernadette Doyle, Adeel Khan, Sakil Kulkarni

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: We aimed to evaluate differences in laboratory tests, bleeding, transfusions, and thrombosis between (1) children without and with cirrhosis and (2) children and adults with cirrhosis, and to correlate thromboelastography (TEG) parameters with biomarkers of hemostasis, bleeding, and transfusions in children and adults with cirrhosis. Methods: This single-center, retrospective study included 20 children without cirrhosis, 40 children with cirrhosis, and 40 adults with cirrhosis who underwent a liver transplant (LT). We collected demographic data, preoperative laboratory values, and intraoperative TEG parameters. Biomarkers of hemostasis just prior to the start of LT surgery were analyzed including international normalized ratio (INR), platelet, fibrinogen level, R time, K time, alpha angle (α), and maximum amplitude (MA). We also collected outcome data including blood loss, transfusion requirements, and thrombosis. Results: A significantly higher proportion of children with cirrhosis had abnormal PT (P = 0.001), platelet (P = 0.001), K time (P = 0.02), and MA (P = 0.05) compared to children without cirrhosis. The incidences of thrombosis, bleeding events, blood loss or PRBC transfusion were not significantly different between these 2 groups. A significantly higher proportion of adults with cirrhosis had abnormal R time (P = 0.01) and alpha angle (P = 0.01) than children with cirrhosis. Conclusions: Children with cirrhosis had defects in fibrinogen and platelets compared to children without cirrhosis at time of LT; however, these abnormalities did not translate into higher rates of bleeding in the former. Adults with cirrhosis had more defects in clotting factors compared to children with cirrhosis.

Original languageEnglish
Pages (from-to)506-513
Number of pages8
JournalJournal of pediatric gastroenterology and nutrition
Volume75
Issue number4
DOIs
StatePublished - Oct 1 2022

Keywords

  • adults
  • bleeding
  • blood product transfusion
  • children
  • cirrhosis
  • clotting
  • liver transplant
  • thromboelastography

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