Characterization of an ETS transcription factor in the sea scallop Chlamys farreri

Hongming Ma, Jia Wang, Bing Wang, Yancui Zhao, Changjian Yang

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10 Scopus citations


We have cloned and characterized a cDNA encoding a putative ETS transcription factor, designated Cf-ets. The Cf-ets encodes a 406 amino acid protein containing a conserved ETS domain and a Pointed domain. Phylogenetic analysis revealed that Cf-ets belongs to the ESE group of ETS transcription factor family. Real-time PCR analysis of Cf-ets expression in adult sea scallop tissues revealed that Cf-ets was expressed mainly in gill and hemocytes, in a constitutive manner. Cf-ets mRNA level in hemocytes increased drastically after microbial challenge indicated its indispensable role in the anti-infection process. Simultaneously, the circulating hemocyte number decreased. In mammals, most ETS transcription factors play indispensable roles in blood cell differentiation and linage commitment during hematopoisis. Cf-ets is therefore likely to be a potential biomarker for hematopoiesis studies in scallops.

Original languageEnglish
Pages (from-to)953-958
Number of pages6
JournalDevelopmental and Comparative Immunology
Issue number9
StatePublished - Sep 2009


  • Cloning
  • Hematopoiesis
  • Hemocyte count
  • Immune challenge
  • Mollusk
  • Phylogeny
  • Real-time PCR
  • Suppressive subtractive hybridization


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