Characterization of age-related follicle changes in mice ovaries using optical coherence tomography

Marcello Amaral, Aixia Sun, Yilin Li, Chao Ren, Anh Truong, Zexu Jiao, Ping Wang, Chao Zhou

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Ovarian tissue cryopreservation is used to frozen preserve ovary tissue for reimplantation, potentially restoring a cancer patient’s fertility after chemo and/or radiation treatment. The selection of ovary tissue containing many primordial and secondary follicles for reimplantation increases the probability of pregnancy, but it is a challenging task. In this work, we used spectral-domain OCT to evaluate the feasibility of non-invasively characterizing the morphology of ovary follicle development and age-related modifications in mice. The measured dimension and age-related number of follicles presented a good agreement with corresponding histological images, demonstrating the potential to use OCT to evaluate ovary tissue for reimplantation.

Original languageEnglish
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII
EditorsJoseph A. Izatt, James G. Fujimoto
PublisherSPIE
ISBN (Electronic)9781510658394
DOIs
StatePublished - 2023
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII 2023 - San Francisco, United States
Duration: Jan 30 2023Feb 1 2023

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12367
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII 2023
Country/TerritoryUnited States
CitySan Francisco
Period01/30/2302/1/23

Keywords

  • Fertility
  • Optical Coherence Tomography
  • Ovarian Tissue Cryopreservation

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