Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus

Azad Bonni, David A. Frank, Chris Schindler, Michael E. Greenberg

Research output: Contribution to journalArticlepeer-review

184 Scopus citations

Abstract

Components of a signaling pathway that couples the ciliary neurotrophic factor (CNTF) receptor to induction of transcription were identified. CNTF stimulated the tyrosine phosphorylation of p91, a protein implicated in interferon signaling pathways, and of two proteins that are distinct but related to p91. Tyrosine-phosphorylated p91 translocated to the nucleus, where p91 and p91-related proteins bound to a DNA sequence found in promoters of genes responsive to CNTF. This DNA sequence, when inserted upstream of a reporter gene, conferred a transcriptional response to CNTF. A pathway that transduces interferon signals may therefore have a more general function in the propagation of responses to certain neurotrophic factors.

Original languageEnglish
Pages (from-to)1575-1579
Number of pages5
JournalScience
Volume262
Issue number5139
DOIs
StatePublished - 1993

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