Characterization of a fibroblast cell from the urinary bladder wall

Douglas E. Coplen, Pamela S. Howard, John W. Duckett, Howard M. Snyder, Edward J. Macarak

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


For the first time we report on the growth, culture, and matrix production characteristics of a cell type isolated from the lamina propria of the urinary bladder wall. A fibroblastlike cell was identified as distinct from bladder detrusor smooth muscle cells and urothelium based on morphology, growth characteristics, and immunohistochemical staining. Characterization of extracellular matrix synthesis by this cell type using35S-methionine metabolic labeling demonstrated that these cells are capable of secreting components of the surrounding connective tissue, including several fibrillar collagens, a basement membrane collagen, and fibronectin.

Original languageEnglish
Pages (from-to)604-608
Number of pages5
JournalIn Vitro Cellular & Developmental Biology - Animal
Issue number9
StatePublished - Sep 1994


  • bladder fibroblasts
  • extracellular matrix


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