Characteristics of respiratory virus infections in autologous hematopoietic stem cell transplantation patients, a prospective study, Bern, Switzerland, 2015–2017

Fabienne Moret, Jonas Marschall, Andrew Atkinson, Sarah Farag, Stefan Zimmerli, Thomas Pabst, Rami Sommerstein

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: The epidemiology of respiratory virus infections (RVI) in patients undergoing autologous haematopoietic stem cell transplantation (auto-SCT) is not well described. Methods: Our goal was to describe the epidemiology of respiratory virus infections (RVI) in patients undergoing autologous haematopoietic stem cell transplantation (auto-SCT) in a single tertiary centre observation study during two respiratory virus seasons (2015–2017). All symptomatic auto-SCT patients were tested for RVI by nasopharyngeal swab. Results: 156 transplantation episodes were included, 69% were male and, the median age was 57 years. We detected 19 RVIs in 156 transplantation episodes (12%). The median time to RVI after hospitalization was 13 days [IQR 7–13] and 15/19 (79%) had a possible nosocomial origin (occurrence ≥ 5 days after admission). The nosocomial infections included 5/15 (33%) ‘severe’ RVIs (3 influenza viruses, 1 parainfluenza virus, and 1 adenovirus) as well as 10/15 (66%) non-severe virus infections (including human rhinovirus and human coronavirus). Conclusion: In approximately 10% of auto-SCT transplantation episodes, an RVI with likely nosocomial origin was detected and included ‘severe viruses’ such as influenza. Our study suggests that infection prevention measures in auto-SCT patients can be improved. Abbreviations: AdV: adenovirus; ALL: acute lymphatic leukaemia; AML: acute myeloid leukaemia; auto-SCT: autologous haematopoietic stem cell transplantation; hCoV: human coronavirus; HD: Hodgkin’s disease; hMPV: human metapneumovirus; HRV: human rhinovirus; HSCT: allogeneic haematopoietic stem cell transplantation; IQR: interquartile range; GCT: germ cell tumour; MM: multiple myeloma; NHL: non-Hodgkin lymphoma; PIV: parainfluenza virus; RSV: respiratory syncytial virus.

Original languageEnglish
Pages (from-to)274-280
Number of pages7
JournalInfectious Diseases
Volume53
Issue number4
DOIs
StatePublished - 2021

Keywords

  • autologous haematopoietic stem cell transplantation
  • nosocomial infection
  • Respiratory virus infection

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