Characteristics of antibiotic-resistant escherichia coli o157:h7 in washington state, 1984-1991

Harold H. Kim, Mansour Samadpour, Linda Grimm, Carla R. Clausen, Thomas E. Besser, Michael Baylor, John M. Kobayashi, Marguerite A. Neill, Fritz D. Schoenknecht, Phillip I. Tarr

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Abstract

The resistance of Escherichia coli O157:H7 to amoxicillin/clavulanic acid, ampicillin, ceftazidime, ceftriaxone, cefuroxime, cephalothin, chloramphenicol, ciprofloxacin, gentamicin, streptomycin, sulfisoxazole, tetracycline, ticarcillin, tobramycin, and trimethoprim-sulfamethoxazole was examined, and resistant strains were characterized. All 56 isolates collected between 1984 and 1987 were susceptible to all antibiotics tested; 13 (7.4%) of 176 strains isolated between 1989 and 1991 were resistant to streptomycin, sulfisoxazole, and tetracycline. A-restriction fragment length polymorphism analysis suggested that the 13 resistant strains belonged to nine different clones. The emerging resistance of E. coli O157:H7 to antibiotics could portend an increased prevalence of this pathogen in food animals that receive antibiotics. Antimicrobial resistance of E. coli O157:H7 could be useful as a rapid epidemiologic marker and as a way to select this pathogen from suspected vehicles of transmission, but this resistance could also complicate therapeutic trials with sulfa-containing antibiotics.

Original languageEnglish
Pages (from-to)1606-1609
Number of pages4
JournalJournal of Infectious Diseases
Volume170
Issue number6
DOIs
StatePublished - Dec 1994
Externally publishedYes

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    Kim, H. H., Samadpour, M., Grimm, L., Clausen, C. R., Besser, T. E., Baylor, M., Kobayashi, J. M., Neill, M. A., Schoenknecht, F. D., & Tarr, P. I. (1994). Characteristics of antibiotic-resistant escherichia coli o157:h7 in washington state, 1984-1991. Journal of Infectious Diseases, 170(6), 1606-1609. https://doi.org/10.1093/infdis/170.6.1606