Chapter 7 Convergence and Extension Movements During Vertebrate Gastrulation

Chunyue Yin, Brian Ciruna, Lilianna Solnica-Krezel

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

53 Scopus citations

Abstract

During vertebrate gastrulation, coordinated cell movements shape the basic body plan. Key components of gastrulation are convergence and extension (C&E) movements, which narrow and lengthen the embryonic tissues, respectively. The rates of C&E movements differ significantly according to the position and the stage of gastrulation. Here, we review the distinct cellular behaviors that define the spatial and temporal patterns of C&E movements, with the special emphasis on zebrafish. We also summarize the molecular regulation of these cellular behaviors and the interplay between different signaling pathways that drive C&E. Finally, to ensure efficient C&E movements, cells must achieve mediolaterally-elongated cell morphology and polarize motile protrusions. We discuss the recent discoveries on the molecular and cellular mechanisms by which the mediolateral cell polarity is established.

Original languageEnglish
Title of host publicationCurrent Topics in Developmental Biology
EditorsThomas Lecuit
Pages163-192
Number of pages30
DOIs
StatePublished - 2009

Publication series

NameCurrent Topics in Developmental Biology
Volume89
ISSN (Print)0070-2153

Keywords

  • Bmp
  • Directed migration
  • G protein
  • Intercalation
  • Mesoderm
  • Noncanonical Wnt signalling
  • Oriented cell division
  • Planar cell polarity
  • Stat3
  • Zebrafish

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