Chaperone-assisted pilus assembly and bacterial attachment

Frederic G. Sauer, Michelle Barnhart, Devapriya Choudhury, Stefan D. Knight, Gabriel Waksman, Scott J. Hultgren

Research output: Contribution to journalReview articlepeer-review

113 Scopus citations


Bacterial pill assembled by the chaperone-usher pathway can mediate microbial attachment, an early step in the establishment of an infection, by binding specifically to sugars present in host tissues. Recent work has begun to reveal the structural basis both of chaperone function in the biogenesis of these pili and of bacterial attachment.

Original languageEnglish
Pages (from-to)548-556
Number of pages9
JournalCurrent Opinion in Structural Biology
Issue number5
StatePublished - 2000

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