Endogenous peptides and structurally similar bacterial heat-stable enterotoxins (ST) bind guanylate cyclase-C (GC-C), resulting in fluid homeostasis or diarrhea, respectively. In this issue of Cell Host & Microbe, Carey et al., show how bats have evolutionarily maintained homeostatic signaling while avoiding pathogenic effects of ST.

Original languageEnglish
Pages (from-to)1335-1337
Number of pages3
JournalCell Host and Microbe
Issue number9
StatePublished - Sep 8 2021


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