TY - JOUR
T1 - Changing the locks on intestinal signaling
AU - Fleckenstein, James M.
AU - Bitoun, Jacob P.
N1 - Publisher Copyright:
© 2021
PY - 2021/9/8
Y1 - 2021/9/8
N2 - Endogenous peptides and structurally similar bacterial heat-stable enterotoxins (ST) bind guanylate cyclase-C (GC-C), resulting in fluid homeostasis or diarrhea, respectively. In this issue of Cell Host & Microbe, Carey et al., show how bats have evolutionarily maintained homeostatic signaling while avoiding pathogenic effects of ST.
AB - Endogenous peptides and structurally similar bacterial heat-stable enterotoxins (ST) bind guanylate cyclase-C (GC-C), resulting in fluid homeostasis or diarrhea, respectively. In this issue of Cell Host & Microbe, Carey et al., show how bats have evolutionarily maintained homeostatic signaling while avoiding pathogenic effects of ST.
UR - http://www.scopus.com/inward/record.url?scp=85115932052&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2021.08.005
DO - 10.1016/j.chom.2021.08.005
M3 - Article
C2 - 34499858
AN - SCOPUS:85115932052
SN - 1931-3128
VL - 29
SP - 1335
EP - 1337
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 9
ER -