Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn’s Disease of the Pouch

Maia Kayal, Parakkal Deepak, Poonam Beniwal-Patel, Laura Raffals, Marla Dubinsky, Shannon Chang, Peter D.R. Higgins, Yue Jiang, Raymond K. Cross, Millie D. Long, Hans H. Herfarth, Edward L. Barnes

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: There is a paucity of data on the real-world effectiveness of therapies in patients with Crohn’s disease of the pouch. METHODS: This was a prospective multicenter study evaluating the primary outcome of remission at 12 months of therapy for Crohn’s disease of the pouch. RESULTS: One hundred thirty-four patients were enrolled. Among the 77 patients with symptoms at baseline, 35 (46.7%) achieved remission at 12 months. Of them, 12 (34.3%) changed therapy. There was no significant association between therapy patterns and remission status. DISCUSSION: Approximately 50% with symptoms at enrollment achieved clinical remission at 12 months, most of whom did so without a change in therapy.

Original languageEnglish
Pages (from-to)584-587
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume119
Issue number3
DOIs
StatePublished - Mar 1 2024

Keywords

  • colectomy
  • ileal pouch anal anastomosis
  • therapy
  • ulcerative colitis

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