Changes in the Myocardial Interstitium and Contribution to the Progression of Heart Failure

Shaina R. Eckhouse, Francis G. Spinale

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

The myocardial interstitium is highly organized and orchestrated, whereby small disruptions in composition, spatial relationships, or content lead to altered myocardial systolic and/or diastolic performance. These changes in extracellular matrix structure and function are important in the progression to heart failure in pressure overload hypertrophy, dilated cardiomyopathy, and ischemic heart disease. The myocardial interstitium is not a passive entity, but rather a complex and dynamic microenvironment that represents an important structural and signaling system within the myocardium.

Original languageEnglish
Pages (from-to)7-20
Number of pages14
JournalHeart Failure Clinics
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Keywords

  • Dilated cardiomyopathy
  • Extracellular matrix
  • Heart failure
  • Interstitium
  • Myocardial infarction
  • Pressure overload hypertrophy

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