TY - JOUR
T1 - Changes in the Myocardial Interstitium and Contribution to the Progression of Heart Failure
AU - Eckhouse, Shaina R.
AU - Spinale, Francis G.
PY - 2012/1
Y1 - 2012/1
N2 - The myocardial interstitium is highly organized and orchestrated, whereby small disruptions in composition, spatial relationships, or content lead to altered myocardial systolic and/or diastolic performance. These changes in extracellular matrix structure and function are important in the progression to heart failure in pressure overload hypertrophy, dilated cardiomyopathy, and ischemic heart disease. The myocardial interstitium is not a passive entity, but rather a complex and dynamic microenvironment that represents an important structural and signaling system within the myocardium.
AB - The myocardial interstitium is highly organized and orchestrated, whereby small disruptions in composition, spatial relationships, or content lead to altered myocardial systolic and/or diastolic performance. These changes in extracellular matrix structure and function are important in the progression to heart failure in pressure overload hypertrophy, dilated cardiomyopathy, and ischemic heart disease. The myocardial interstitium is not a passive entity, but rather a complex and dynamic microenvironment that represents an important structural and signaling system within the myocardium.
KW - Dilated cardiomyopathy
KW - Extracellular matrix
KW - Heart failure
KW - Interstitium
KW - Myocardial infarction
KW - Pressure overload hypertrophy
UR - http://www.scopus.com/inward/record.url?scp=82955246213&partnerID=8YFLogxK
U2 - 10.1016/j.hfc.2011.08.012
DO - 10.1016/j.hfc.2011.08.012
M3 - Review article
C2 - 22108723
AN - SCOPUS:82955246213
SN - 1551-7136
VL - 8
SP - 7
EP - 20
JO - Heart Failure Clinics
JF - Heart Failure Clinics
IS - 1
ER -