TY - JOUR
T1 - Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares
T2 - Findings from one site of the MAPP Research Network
AU - Sutcliffe, Siobhan
AU - Colditz, Graham A.
AU - Pakpahan, Ratna
AU - Bradley, Catherine S.
AU - Goodman, Melody S.
AU - Andriole, Gerald L.
AU - Lai, H. Henry
N1 - Publisher Copyright:
© 2013 Wiley Periodicals, Inc. © 2013 Wiley Periodicals, Inc.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Aims To provide the first description and quantification of symptom changes during interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome symptom exacerbations ("flares"). Methods Participants at one site of the Trans-Multidisciplinary Approaches to the study of chronic Pelvic Pain Epidemiology and Phenotyping Study completed two 10-day diaries over the 1-year study follow-up period, one at baseline and one during their first flare (if not at baseline). On each day of the diary, participants reported whether they were currently experiencing a flare, defined as "symptoms that are much worse than usual" for at least 1 day, and their levels of urination-related pain, pelvic pain, urgency, and frequency on a scale of 0-10. Linear mixed models were used to calculate mean changes in symptoms between non-flare and flare days from the same participant. Results Eighteen of 27 women and 9 of 29 men reported at least one flare during follow-up, for a total of 281 non-flare and 210 flare days. Of these participants, 44.4% reported one flare, 29.6% reported two flares, and 25.9% reported ≥3 flares over the combined 20-day diary observation period, with reported flares ranging in duration from 1 day to >2 weeks. During these flares, each of the main symptoms worsened significantly by a mean of at least two points and total symptoms worsened by a mean of 11 points for both sexes (all P ≤ 0.01). Conclusions Flares are common and correspond to a global worsening of urologic and pelvic pain symptoms. Neurourol. Urodynam. 34:188-195, 2015.
AB - Aims To provide the first description and quantification of symptom changes during interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome symptom exacerbations ("flares"). Methods Participants at one site of the Trans-Multidisciplinary Approaches to the study of chronic Pelvic Pain Epidemiology and Phenotyping Study completed two 10-day diaries over the 1-year study follow-up period, one at baseline and one during their first flare (if not at baseline). On each day of the diary, participants reported whether they were currently experiencing a flare, defined as "symptoms that are much worse than usual" for at least 1 day, and their levels of urination-related pain, pelvic pain, urgency, and frequency on a scale of 0-10. Linear mixed models were used to calculate mean changes in symptoms between non-flare and flare days from the same participant. Results Eighteen of 27 women and 9 of 29 men reported at least one flare during follow-up, for a total of 281 non-flare and 210 flare days. Of these participants, 44.4% reported one flare, 29.6% reported two flares, and 25.9% reported ≥3 flares over the combined 20-day diary observation period, with reported flares ranging in duration from 1 day to >2 weeks. During these flares, each of the main symptoms worsened significantly by a mean of at least two points and total symptoms worsened by a mean of 11 points for both sexes (all P ≤ 0.01). Conclusions Flares are common and correspond to a global worsening of urologic and pelvic pain symptoms. Neurourol. Urodynam. 34:188-195, 2015.
KW - bladder pain syndrome
KW - chronic pelvic pain syndrome
KW - chronic prostatitis
KW - flare
KW - interstitial cystitis
KW - symptom exacerbation
UR - http://www.scopus.com/inward/record.url?scp=84922750982&partnerID=8YFLogxK
U2 - 10.1002/nau.22534
DO - 10.1002/nau.22534
M3 - Article
C2 - 24273163
AN - SCOPUS:84922750982
SN - 0733-2467
VL - 34
SP - 188
EP - 195
JO - Neurourology and Urodynamics
JF - Neurourology and Urodynamics
IS - 2
ER -