TY - JOUR
T1 - Change in Caregiver Health-Related Quality of Life from before to Early after Surgery
T2 - SUSTAIN-IT Study
AU - Chuzi, Sarah
AU - Wilcox, Jane E.
AU - Kao, Andrew
AU - Spertus, John A.
AU - Hsich, Eileen
AU - Dew, Mary Amanda
AU - Yancy, Clyde W.
AU - Pham, Duc T.
AU - Hartupee, Justin
AU - Petty, Michael
AU - Cotts, William
AU - Pamboukian, Salpy V.
AU - Pagani, Francis D.
AU - Lampert, Brent
AU - Johnson, Maryl
AU - Murray, Margaret
AU - Takeda, Koji
AU - Yuzefpolskaya, Melana
AU - Silvestry, Scott
AU - Kirklin, James K.
AU - Wu, Tingqing
AU - Andrei, Adin Cristian
AU - Baldridge, Abigail
AU - Grady, Kathleen L.
N1 - Funding Information:
Dr Jane received grant support from the American Heart Association and the National Institutes of Health; is a consultant for Amgen, Abbott, Abiomed, and Novartis; and is on the advisory board of Abiomed and Cytokinetics. Dr Kao participated in the advisory board for CareDx and Bioventrix. Dr Spertus is a consultant at Amgen, Novartis, Bayer, Myokardia, and Janssen; on the scientific advisory board of United HealthCare; on the board of directors of BlueCross BlueShield, Kansas City; and is the copyright holder to the Kansas City Cardiomyopathy Questionnaire. Dr Yancy received spousal employment from Abbott Labs Inc. Dr Petty received speaking honorarium from Abbott Inc. M. Murray is a consultant on a research project at GE Healthcare. Dr Silvestry is a consultant at Abiomed, Medtronic, Syncardia, and Abbott. Dr Kirklin is a director of the DCC for STS INTERMACS; and received grant support from the National Institutes of Health/National Institute on Aging. Dr Grady is a consultant at Amgen Inc; is a paid lecturer for the American Heart Association; and received grant support from the National Institutes of Health (National Institute on Aging and National Heart, Lung, and Blood Institute).
Funding Information:
This work was sponsored by the National Institutes of Health, National Institute on Aging, SUSTAIN-IT (Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Circulatory Support?; 01AG047416, Dr Grady [principal investigator]); ClinicalTrials.gov Unique Identifier: NCT02568930.
Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - BACKGROUND: Information about health-related quality of life (HRQOL) among caregivers of older patients with heart failure who receive heart transplantation (HT) and mechanical circulatory support (MCS) is sparse. We describe differences and factors associated with change in HRQOL before and early post-surgery among caregivers of older heart failure patients who underwent 3 surgical therapies: HT with pretransplant MCS (HT MCS), HT without pretransplant MCS (HT non-MCS), and long-term MCS. METHODS: Caregivers of older patients (60-80 years) from 13 US sites completed the EQ-5D-3 L visual analog scale (0 [worst]-100 [best] imaginable health state) and dimensions before and 3 and 6 months post-surgery. Analyses included linear regression, t tests, and nonparametric tests. RESULTS: Among 227 caregivers (HT MCS=54, HT non-MCS=76, long-term MCS=97; median age 62.7 years, 30% male, 84% White, 83% spouse/partner), EQ-5D visual analog scale scores were high before (84.8±14.1) and at 3 (84.7±13.0) and 6 (83.9±14.7) months post-surgery, without significant differences among groups or changes over time. Patient pulmonary hypertension presurgery (β=-13.72 [95% CI, -21.07 to -6.36]; P<0.001) and arrhythmia from 3 to 6 months post-operatively (β=-14.22 [95% CI, -27.41 to -1.02]; P=0.035) were associated with the largest decrements in caregiver HRQOL; patient marital/partner status (β=6.21 [95% CI, 1.34-11.08]; P=0.013) and presurgery coronary disease (β=8.98 [95% CI, 4.07-13.89]; P<0.001) were associated with the largest improvements. CONCLUSIONS: Caregivers of older patients undergoing heart failure surgeries reported overall high HRQOL before and early post-surgery. Understanding factors associated with caregiver HRQOL may inform decision-making and support needs. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02568930.
AB - BACKGROUND: Information about health-related quality of life (HRQOL) among caregivers of older patients with heart failure who receive heart transplantation (HT) and mechanical circulatory support (MCS) is sparse. We describe differences and factors associated with change in HRQOL before and early post-surgery among caregivers of older heart failure patients who underwent 3 surgical therapies: HT with pretransplant MCS (HT MCS), HT without pretransplant MCS (HT non-MCS), and long-term MCS. METHODS: Caregivers of older patients (60-80 years) from 13 US sites completed the EQ-5D-3 L visual analog scale (0 [worst]-100 [best] imaginable health state) and dimensions before and 3 and 6 months post-surgery. Analyses included linear regression, t tests, and nonparametric tests. RESULTS: Among 227 caregivers (HT MCS=54, HT non-MCS=76, long-term MCS=97; median age 62.7 years, 30% male, 84% White, 83% spouse/partner), EQ-5D visual analog scale scores were high before (84.8±14.1) and at 3 (84.7±13.0) and 6 (83.9±14.7) months post-surgery, without significant differences among groups or changes over time. Patient pulmonary hypertension presurgery (β=-13.72 [95% CI, -21.07 to -6.36]; P<0.001) and arrhythmia from 3 to 6 months post-operatively (β=-14.22 [95% CI, -27.41 to -1.02]; P=0.035) were associated with the largest decrements in caregiver HRQOL; patient marital/partner status (β=6.21 [95% CI, 1.34-11.08]; P=0.013) and presurgery coronary disease (β=8.98 [95% CI, 4.07-13.89]; P<0.001) were associated with the largest improvements. CONCLUSIONS: Caregivers of older patients undergoing heart failure surgeries reported overall high HRQOL before and early post-surgery. Understanding factors associated with caregiver HRQOL may inform decision-making and support needs. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02568930.
KW - aged
KW - caregivers
KW - heart failure
KW - heart-assist devices
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85168222177&partnerID=8YFLogxK
U2 - 10.1161/CIRCHEARTFAILURE.122.010038
DO - 10.1161/CIRCHEARTFAILURE.122.010038
M3 - Article
C2 - 37345518
AN - SCOPUS:85168222177
SN - 1941-3289
VL - 16
SP - e010038
JO - Circulation: Heart Failure
JF - Circulation: Heart Failure
IS - 8
ER -