## Abstract

A chamber stiffness (K_{LV})-transmitral flow (E-wave) deceleration time relation has been invasively validated in dogs with the use of average stiffness [(ΔP/ΔV)_{avg}]. K_{LV} is equivalent to k_{E}, the (E-wave) stiffness of the parameterized diastolic filling model. Prediction and validation of 1) (ΔP/ΔV)_{avg} in terms of k_{E}, 2) early rapid-filling stiffness [(ΔP/ΔV)_{E}] in terms of k_{E}, and 3) passive (postdiastasis) chamber stiffness [(ΔP/ΔV)_{PD}] from A waves in terms of the stiffness parameter for the Doppler A wave (k_{A}) have not been achieved. Simultaneous micromanometric left ventricular (LV) pressure (LVP) and transmitral flow from 131 subjects were analyzed. (ΔP)_{avg} and (ΔV)_{avg} utilized the minimum LVP-LV end-diastolic pressure interval. (ΔP/ΔV)_{E} utilized ΔP and ΔV from minimum LVP to E-wave termination. (ΔP/ΔV)_{PD} utilized atrial systolic ΔP and ΔV. E- and A-wave analysis generated k_{E} and k_{A}. For all subjects, noninvasive-invasive relations yielded the following equations: k_{E} = 1,401·(ΔP/ΔV)_{avg} + 59.2 (r = 0.84) and k_{E} = 229.0·(ΔP/ΔV)_{E} + 112 (r = 0.80). For subjects with diastasis (n = 113), k_{A} = 1,640·(ΔP/ΔV)_{PD} - 8.40 (r = 0.89). As predicted, k_{A} showed excellent correlation with (ΔP/ΔV)_{PD}; k_{E} correlated highly with (ΔP/ΔV)_{avg}. In vivo validation of average, early, and passive chamber stiffness facilitates quantitative, noninvasive diastolic function assessment from transmitral flow.

Original language | English |
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Pages (from-to) | 154-162 |

Number of pages | 9 |

Journal | Journal of Applied Physiology |

Volume | 91 |

Issue number | 1 |

State | Published - 2001 |

## Keywords

- Diastole
- Echocardiography
- Hemodynamics
- Mathematical modeling
- Ventricles