Challenges to curing primary brain tumours

Kenneth Aldape; Kevin M. Brindle; Louis Chesler; Rajesh Chopra; Amar Gajjar; Mark R. Gilbert; Nicholas Gottardo; David H. Gutmann; Darren Hargrave; Eric C. Holland; David T.W. Jones; Johanna A. Joyce; Pamela Kearns; Mark W. Kieran; Ingo K. Mellinghoff; Melinda Merchant; Stefan M. Pfister; Steven M. Pollard; Vijay Ramaswamy; Jeremy N. Rich; Giles W. Robinson; David H. Rowitch; John H. Sampson; Michael D. Taylor; Paul Workman; Richard J. Gilbertson

doi:10.1038/s41571-019-0177-5

Challenges to curing primary brain tumours

Kenneth Aldape, Kevin M. Brindle, Louis Chesler, Rajesh Chopra, Amar Gajjar, Mark R. Gilbert, Nicholas Gottardo, David H. Gutmann, Darren Hargrave, Eric C. Holland, David T.W. Jones, Johanna A. Joyce, Pamela Kearns, Mark W. Kieran, Ingo K. Mellinghoff, Melinda Merchant, Stefan M. Pfister, Steven M. Pollard, Vijay Ramaswamy, Jeremy N. RichGiles W. Robinson, David H. Rowitch, John H. Sampson, Michael D. Taylor, Paul Workman, Richard J. Gilbertson

Research output: Contribution to journal › Article › peer-review

396 Scopus citations

Abstract

Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.

Original language	English
Pages (from-to)	509-520
Number of pages	12
Journal	Nature Reviews Clinical Oncology
Volume	16
Issue number	8
DOIs	https://doi.org/10.1038/s41571-019-0177-5
State	Published - Aug 1 2019

Access to Document

10.1038/s41571-019-0177-5

Cite this

Aldape, K., Brindle, K. M., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., Gottardo, N., Gutmann, D. H., Hargrave, D., Holland, E. C., Jones, D. T. W., Joyce, J. A., Kearns, P., Kieran, M. W., Mellinghoff, I. K., Merchant, M., Pfister, S. M., Pollard, S. M., Ramaswamy, V., ... Gilbertson, R. J. (2019). Challenges to curing primary brain tumours. Nature Reviews Clinical Oncology, 16(8), 509-520. https://doi.org/10.1038/s41571-019-0177-5

@article{8b808ac3c7b74f478d43f02650206841,

title = "Challenges to curing primary brain tumours",

abstract = "Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.",

author = "Kenneth Aldape and Brindle, {Kevin M.} and Louis Chesler and Rajesh Chopra and Amar Gajjar and Gilbert, {Mark R.} and Nicholas Gottardo and Gutmann, {David H.} and Darren Hargrave and Holland, {Eric C.} and Jones, {David T.W.} and Joyce, {Johanna A.} and Pamela Kearns and Kieran, {Mark W.} and Mellinghoff, {Ingo K.} and Melinda Merchant and Pfister, {Stefan M.} and Pollard, {Steven M.} and Vijay Ramaswamy and Rich, {Jeremy N.} and Robinson, {Giles W.} and Rowitch, {David H.} and Sampson, {John H.} and Taylor, {Michael D.} and Paul Workman and Gilbertson, {Richard J.}",

note = "Funding Information: R.J.G. gratefully acknowledges financial support from the US NIH (grants P01CA96832 and R0CA1129541), Cancer Research UK, the Mathile Family Foundation, Cure Search and the Sohn Foundation. Publisher Copyright: {\textcopyright} 2019, Springer Nature Limited.",

year = "2019",

month = aug,

day = "1",

doi = "10.1038/s41571-019-0177-5",

language = "English",

volume = "16",

pages = "509--520",

journal = "Nature Reviews Clinical Oncology",

issn = "1759-4774",

number = "8",

}

Aldape, K, Brindle, KM, Chesler, L, Chopra, R, Gajjar, A, Gilbert, MR, Gottardo, N, Gutmann, DH, Hargrave, D, Holland, EC, Jones, DTW, Joyce, JA, Kearns, P, Kieran, MW, Mellinghoff, IK, Merchant, M, Pfister, SM, Pollard, SM, Ramaswamy, V, Rich, JN, Robinson, GW, Rowitch, DH, Sampson, JH, Taylor, MD, Workman, P & Gilbertson, RJ 2019, 'Challenges to curing primary brain tumours', Nature Reviews Clinical Oncology, vol. 16, no. 8, pp. 509-520. https://doi.org/10.1038/s41571-019-0177-5

TY - JOUR

T1 - Challenges to curing primary brain tumours

AU - Aldape, Kenneth

AU - Brindle, Kevin M.

AU - Chesler, Louis

AU - Chopra, Rajesh

AU - Gajjar, Amar

AU - Gilbert, Mark R.

AU - Gottardo, Nicholas

AU - Gutmann, David H.

AU - Hargrave, Darren

AU - Holland, Eric C.

AU - Jones, David T.W.

AU - Joyce, Johanna A.

AU - Kearns, Pamela

AU - Kieran, Mark W.

AU - Mellinghoff, Ingo K.

AU - Merchant, Melinda

AU - Pfister, Stefan M.

AU - Pollard, Steven M.

AU - Ramaswamy, Vijay

AU - Rich, Jeremy N.

AU - Robinson, Giles W.

AU - Rowitch, David H.

AU - Sampson, John H.

AU - Taylor, Michael D.

AU - Workman, Paul

AU - Gilbertson, Richard J.

N1 - Funding Information: R.J.G. gratefully acknowledges financial support from the US NIH (grants P01CA96832 and R0CA1129541), Cancer Research UK, the Mathile Family Foundation, Cure Search and the Sohn Foundation. Publisher Copyright: © 2019, Springer Nature Limited.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.

AB - Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.

UR - http://www.scopus.com/inward/record.url?scp=85061232481&partnerID=8YFLogxK

U2 - 10.1038/s41571-019-0177-5

DO - 10.1038/s41571-019-0177-5

M3 - Article

C2 - 30733593

AN - SCOPUS:85061232481

SN - 1759-4774

VL - 16

SP - 509

EP - 520

JO - Nature Reviews Clinical Oncology

JF - Nature Reviews Clinical Oncology

IS - 8

ER -

Challenges to curing primary brain tumours

Abstract

Access to Document

Other files and links

Fingerprint

Cite this