@article{8b808ac3c7b74f478d43f02650206841,
title = "Challenges to curing primary brain tumours",
abstract = "Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.",
author = "Kenneth Aldape and Brindle, {Kevin M.} and Louis Chesler and Rajesh Chopra and Amar Gajjar and Gilbert, {Mark R.} and Nicholas Gottardo and Gutmann, {David H.} and Darren Hargrave and Holland, {Eric C.} and Jones, {David T.W.} and Joyce, {Johanna A.} and Pamela Kearns and Kieran, {Mark W.} and Mellinghoff, {Ingo K.} and Melinda Merchant and Pfister, {Stefan M.} and Pollard, {Steven M.} and Vijay Ramaswamy and Rich, {Jeremy N.} and Robinson, {Giles W.} and Rowitch, {David H.} and Sampson, {John H.} and Taylor, {Michael D.} and Paul Workman and Gilbertson, {Richard J.}",
note = "Funding Information: R.J.G. gratefully acknowledges financial support from the US NIH (grants P01CA96832 and R0CA1129541), Cancer Research UK, the Mathile Family Foundation, Cure Search and the Sohn Foundation. Publisher Copyright: {\textcopyright} 2019, Springer Nature Limited.",
year = "2019",
month = aug,
day = "1",
doi = "10.1038/s41571-019-0177-5",
language = "English",
volume = "16",
pages = "509--520",
journal = "Nature Reviews Clinical Oncology",
issn = "1759-4774",
number = "8",
}