Challenges of implementing pharmacogenetics in the critical care environment

Bradley D. Freeman, Howard L. McLeod

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The publication of the human genome sequence has generated great enthusiasm for the potential of gene-based technologies to transform many facets of medical care. Pharmacogenetics - for example, the use of an individual's genetic profile to optimize drug prescription - has generated particular interest, but so far most efforts in this field have focused on sub-acute or chronic illnesses, such as cancer and cardiovascular disease. By contrast, little attention has been devoted to the potential of pharmacogenetics in guiding drug selection for acutely ill patients in the critical care environment. Although such an approach has theoretical appeal as a means of enhancing quality and improving outcomes in this setting, several obstacles exist to bringing this technology to clinical fruition.

Original languageEnglish
Pages (from-to)88-93
Number of pages6
JournalNature Reviews Drug Discovery
Issue number1
StatePublished - Jan 2004


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