Challenges for clinical trials to treat progressive multifocal leukoencephalopathy

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Progressive multifocal leukoencephalopathy is a lethal complication of immunodeficiency for which no direct therapy has been achieved. The issues that have made this disease especially difficult to address are discussed, and an outline for development of future interventions is provided. A controlled trial of therapy utilizing an international group of trial groups is proposed.

Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalJournal of NeuroVirology
Issue numberSUPPL. 1
StatePublished - Jun 13 2003


  • AIDS
  • HIV
  • Human immunodeficiency virus
  • JC virus
  • PML
  • Progressive multifocal leukoencephalopathy


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