Challenges and opportunities in abdominal aortic aneurysm research

Momtaz Wassef, Gilbert R. Upchurch, Helena Kuivaniemi, Robert W. Thompson, M. D. Tilson

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Abstract: Abdominal Aortic Aneurysms (AAAs) are associated with advanced age, male gender, cigarette smoking, atherosclerosis, hypertension, and genetic predisposition. Basic research studies have led to a better understanding of aneurysm disease over the past two decades. There has also been a growing appreciation that fundamental knowledge regarding the process of aneurysmal degeneration is still somewhat limted. Opportunities in research include: 1) the investigation of potential new mechanism-based pharmacologic interventions; 2) identify the genetic basis for an inherited predisposition; 3) develop and refine noninvasive approaches for the early detection; 4) examine potential novel surgical approaches and design new biomaterials; and 5) initiate and promote awareness programs for diagnosis and treatment of aortic aneurysms. The optimal approach to addressing these issues will require integrative, multidisciplinary research programs that involve basic scientists working in concert with vascular and cardiothoracic surgeons, as well as other clinical specialists with expertise in vascular disease.

Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalJournal of Vascular Surgery
Volume45
Issue number1
DOIs
StatePublished - Jan 2007

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