TY - JOUR
T1 - Challenges and opportunities in abdominal aortic aneurysm research
AU - Wassef, Momtaz
AU - Upchurch, Gilbert R.
AU - Kuivaniemi, Helena
AU - Thompson, Robert W.
AU - Tilson, M. D.
PY - 2007/1
Y1 - 2007/1
N2 - Abstract: Abdominal Aortic Aneurysms (AAAs) are associated with advanced age, male gender, cigarette smoking, atherosclerosis, hypertension, and genetic predisposition. Basic research studies have led to a better understanding of aneurysm disease over the past two decades. There has also been a growing appreciation that fundamental knowledge regarding the process of aneurysmal degeneration is still somewhat limted. Opportunities in research include: 1) the investigation of potential new mechanism-based pharmacologic interventions; 2) identify the genetic basis for an inherited predisposition; 3) develop and refine noninvasive approaches for the early detection; 4) examine potential novel surgical approaches and design new biomaterials; and 5) initiate and promote awareness programs for diagnosis and treatment of aortic aneurysms. The optimal approach to addressing these issues will require integrative, multidisciplinary research programs that involve basic scientists working in concert with vascular and cardiothoracic surgeons, as well as other clinical specialists with expertise in vascular disease.
AB - Abstract: Abdominal Aortic Aneurysms (AAAs) are associated with advanced age, male gender, cigarette smoking, atherosclerosis, hypertension, and genetic predisposition. Basic research studies have led to a better understanding of aneurysm disease over the past two decades. There has also been a growing appreciation that fundamental knowledge regarding the process of aneurysmal degeneration is still somewhat limted. Opportunities in research include: 1) the investigation of potential new mechanism-based pharmacologic interventions; 2) identify the genetic basis for an inherited predisposition; 3) develop and refine noninvasive approaches for the early detection; 4) examine potential novel surgical approaches and design new biomaterials; and 5) initiate and promote awareness programs for diagnosis and treatment of aortic aneurysms. The optimal approach to addressing these issues will require integrative, multidisciplinary research programs that involve basic scientists working in concert with vascular and cardiothoracic surgeons, as well as other clinical specialists with expertise in vascular disease.
UR - http://www.scopus.com/inward/record.url?scp=33845953683&partnerID=8YFLogxK
U2 - 10.1016/j.jvs.2006.09.004
DO - 10.1016/j.jvs.2006.09.004
M3 - Article
C2 - 17210410
AN - SCOPUS:33845953683
SN - 0741-5214
VL - 45
SP - 192
EP - 198
JO - Journal of Vascular Surgery
JF - Journal of Vascular Surgery
IS - 1
ER -