Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro

Keyphrases

• Tau Fibrils 100%
• Alpha-synuclein (α-syn) 100%
• Isostere 100%
• Chalcone 100%
• α-Synuclein Fibrils 100%
• Five-membered Heterocycles 100%
• Positron Emission Tomography 33%
• Parkinson's Disease 33%
• Double Bond 33%
• Amyloid beta 33%
• Low Affinity 33%
• Ring Systems 33%
• Imaging Studies 33%
• Structure-activity Relationship Studies 33%
• Isoxazole 33%
• α-synuclein Aggregation 33%
• Enones 33%
• Pyrazole Ring 33%
• Secondary Lead 33%

Chemistry

• Chalcone 100%
• Heterocyclic Compound 100%
• Double Bond 50%
• Structure-Activity Relationship 50%
• Cyclic Structure 50%
• Positron 50%
• Surface Area 50%
• Beta-Amyloid 50%
• Isoxazole 50%
• Enone 50%
• Pyrazole 50%
• Lead Compound 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Alpha Synuclein 100%
• Chalcone Derivative 100%
• Parkinson's Disease 20%
• Structure Activity Relationship 20%
• Double Bond 20%
• Lead Compound 20%
• Amyloid Protein 20%
• Pyrazole 20%
• Chalcone 20%
• Isoxazole 20%