@article{0fdc2a6e27b44648b7b6cb35cefbc28c,
title = "Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro",
abstract = "A series of chalcone and heterocyclic isosteres, in which the enone moiety was replaced with an isoxazole and pyrazole ring system, was synthesized and their affinities for alpha synuclein (Asyn), amyloid beta (Aβ), and tau fibrils were measured in vitro. The compounds were found to have a modest affinity and selectivity for Asyn versus Aβ fibrils and low affinity for tau fibrils. Insertion of a double bond to increase the extendable surface area resulted in an increase in affinity and improvement in selectivity for Asyn versus Aβ and tau fibrils. The results of this study indicate that compound 11 is a secondary lead compound for structure-activity relationship studies aimed at identifying a suitable compound for positron emission tomography-imaging studies of insoluble Asyn aggregates in Parkinson's disease.",
author = "Hsieh, {Chia Ju} and Kuiying Xu and Iljung Lee and Graham, {Thomas J.A.} and Zhude Tu and Dhruva Dhavale and Paul Kotzbauer and Mach, {Robert H.}",
note = "Funding Information: Funding for the Michael J. Fox Alpha Synuclein Imaging Consortium was provided by the Michael J. Fox Foundation. The other members of the Michael J. Fox Alpha Synuclein Imaging Consortium include Jamie Eberling, Eugene Johnson, and Kalpana M. Merchant from the Michael J. Fox Foundation; Chester A. Mathis, William E. Klunk, and N. Scott Mason from the University of Pittsburgh Medical Center; Dale Mitchell, Wolfgang Schmidt, and David Hardick from BioFocus Charles River; Edilio Borroni, Luca Golbi, Michael Horner, and Kevin Nash from Roche; and Joel Mercier from UCB. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = apr,
day = "30",
doi = "10.1021/acsomega.7b01897",
language = "English",
volume = "3",
pages = "4486--4493",
journal = "ACS Omega",
issn = "2470-1343",
number = "4",
}