TY - GEN
T1 - Cervical Cancer Tumor Delineation for Brachytherapy Using Diffusion Weighted Images
AU - Gach, H. Michael
AU - Mackey, Stacie L.
AU - Kim, Taeho
AU - Zoberi, Jacqueline E.
AU - Garcia-Ramirez, Jose
AU - Grigsby, Perry W.
AU - Markovina, Stephanie S.
AU - Lin, Alexander
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2023
Y1 - 2023
N2 - The hypothesis that cervical cancer tumor delineation is superior using diffusion weighted imaging (DWI) compared to the corresponding apparent diffusion coefficient (ADC) maps was tested. A radiation oncologist analyzed brachytherapy planning structural MRIs, diffusion weighted MRIs (DW-MRIs), and ADC maps for 19 patients with locally advanced cervical cancer. Pre-treatment MRIs were analyzed separately from post-implant brachytherapy planning MRIs to account for differences in pulse sequences and artifacts associated with the titanium tandem and ovoid implants. DWIs (b = 800 mm2/s) had significantly higher mean contrast ratios (CRs) pre-treatment (0.72 ± 0.34 vs. 0.24 ± 0.15) and post-implant (0.70 ± 0.36 vs. 0.17 ± 0.16) compared to ADCs. For pre-treatment DWIs, mean tumor and uterus signal-to-noise ratios (SNRs) were 54.90 ± 20.30 and 32.36 ± 11.82, respectively. For post-implant DWIs, mean tumor and uterus SNRs were 28.51 ± 10.57 and 16.93 ± 5.13, respectively. Mean contrast-to-noise ratio (CNRs) were 22.54 ± 10.98 pre-treatment and 11.58 ± 6.98 post-implant. DWIs had significantly higher CRs between tumor and uterus tissues compared to ADC maps.
AB - The hypothesis that cervical cancer tumor delineation is superior using diffusion weighted imaging (DWI) compared to the corresponding apparent diffusion coefficient (ADC) maps was tested. A radiation oncologist analyzed brachytherapy planning structural MRIs, diffusion weighted MRIs (DW-MRIs), and ADC maps for 19 patients with locally advanced cervical cancer. Pre-treatment MRIs were analyzed separately from post-implant brachytherapy planning MRIs to account for differences in pulse sequences and artifacts associated with the titanium tandem and ovoid implants. DWIs (b = 800 mm2/s) had significantly higher mean contrast ratios (CRs) pre-treatment (0.72 ± 0.34 vs. 0.24 ± 0.15) and post-implant (0.70 ± 0.36 vs. 0.17 ± 0.16) compared to ADCs. For pre-treatment DWIs, mean tumor and uterus signal-to-noise ratios (SNRs) were 54.90 ± 20.30 and 32.36 ± 11.82, respectively. For post-implant DWIs, mean tumor and uterus SNRs were 28.51 ± 10.57 and 16.93 ± 5.13, respectively. Mean contrast-to-noise ratio (CNRs) were 22.54 ± 10.98 pre-treatment and 11.58 ± 6.98 post-implant. DWIs had significantly higher CRs between tumor and uterus tissues compared to ADC maps.
KW - Diffusion weighted imaging
KW - MRI
KW - apparent diffusion coefficient
KW - cervical cancer
KW - tumor delineation
UR - https://www.scopus.com/pages/publications/85171996427
U2 - 10.1007/978-3-031-40579-2_12
DO - 10.1007/978-3-031-40579-2_12
M3 - Conference contribution
AN - SCOPUS:85171996427
SN - 9783031405785
T3 - Lecture Notes in Networks and Systems
SP - 114
EP - 122
BT - Advances in Systems Engineering - Proceedings of the 30th International Conference on Systems Engineering, ICSEng 2023
A2 - Selvaraj, Henry
A2 - Chmaj, Grzegorz
A2 - Zydek, Dawid
PB - Springer Science and Business Media Deutschland GmbH
T2 - Advances in Systems Engineering - Proceedings of the 30th International Conference on Systems Engineering, ICSEng 2023
Y2 - 22 August 2023 through 24 August 2023
ER -