Cervical Cancer Tumor Delineation for Brachytherapy Using Diffusion Weighted Images

H. Michael Gach, Stacie L. Mackey, Taeho Kim, Jacqueline E. Zoberi, Jose Garcia-Ramirez, Perry W. Grigsby, Stephanie S. Markovina, Alexander J. Lin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The hypothesis that cervical cancer tumor delineation is superior using diffusion weighted imaging (DWI) compared to the corresponding apparent diffusion coefficient (ADC) maps was tested. A radiation oncologist analyzed brachytherapy planning structural MRIs, diffusion weighted MRIs (DW-MRIs), and ADC maps for 19 patients with locally advanced cervical cancer. Pre-treatment MRIs were analyzed separately from post-implant brachytherapy planning MRIs to account for differences in pulse sequences and artifacts associated with the titanium tandem and ovoid implants. DWIs (b = 800 mm2/s) had significantly higher mean contrast ratios (CRs) pre-treatment (0.72 ± 0.34 vs. 0.24 ± 0.15) and post-implant (0.70 ± 0.36 vs. 0.17 ± 0.16) compared to ADCs. For pre-treatment DWIs, mean tumor and uterus signal-to-noise ratios (SNRs) were 54.90 ± 20.30 and 32.36 ± 11.82, respectively. For post-implant DWIs, mean tumor and uterus SNRs were 28.51 ± 10.57 and 16.93 ± 5.13, respectively. Mean contrast-to-noise ratio (CNRs) were 22.54 ± 10.98 pre-treatment and 11.58 ± 6.98 post-implant. DWIs had significantly higher CRs between tumor and uterus tissues compared to ADC maps.

Original languageEnglish
Title of host publicationAdvances in Systems Engineering - Proceedings of the 30th International Conference on Systems Engineering, ICSEng 2023
EditorsHenry Selvaraj, Grzegorz Chmaj, Dawid Zydek
PublisherSpringer Science and Business Media Deutschland GmbH
Pages114-122
Number of pages9
ISBN (Print)9783031405785
DOIs
StatePublished - 2023
EventAdvances in Systems Engineering - Proceedings of the 30th International Conference on Systems Engineering, ICSEng 2023 - Las Vegas, United States
Duration: Aug 22 2023Aug 24 2023

Publication series

NameLecture Notes in Networks and Systems
Volume761 LNNS
ISSN (Print)2367-3370
ISSN (Electronic)2367-3389

Conference

ConferenceAdvances in Systems Engineering - Proceedings of the 30th International Conference on Systems Engineering, ICSEng 2023
Country/TerritoryUnited States
CityLas Vegas
Period08/22/2308/24/23

Keywords

  • Diffusion weighted imaging
  • MRI
  • apparent diffusion coefficient
  • cervical cancer
  • tumor delineation

Fingerprint

Dive into the research topics of 'Cervical Cancer Tumor Delineation for Brachytherapy Using Diffusion Weighted Images'. Together they form a unique fingerprint.

Cite this