Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

Jose A. Mazzitelli; Leon C.D. Smyth; Kevin A. Cross; Taitea Dykstra; Jerry Sun; Siling Du; Tornike Mamuladze; Igor Smirnov; Justin Rustenhoven; Jonathan Kipnis

doi:10.1038/s41593-022-01029-1

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

Jose A. Mazzitelli, Leon C.D. Smyth, Kevin A. Cross, Taitea Dykstra, Jerry Sun, Siling Du, Tornike Mamuladze, Igor Smirnov, Justin Rustenhoven, Jonathan Kipnis

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura–skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.

Original language	English
Pages (from-to)	555-560
Number of pages	6
Journal	Nature neuroscience
Volume	25
Issue number	5
DOIs	https://doi.org/10.1038/s41593-022-01029-1
State	Published - May 2022

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title = "Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels",

abstract = "It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura–skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.",

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AU - Smyth, Leon C.D.

AU - Cross, Kevin A.

AU - Dykstra, Taitea

AU - Sun, Jerry

AU - Du, Siling

AU - Mamuladze, Tornike

AU - Smirnov, Igor

AU - Rustenhoven, Justin

AU - Kipnis, Jonathan

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AB - It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura–skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.

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ER -

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

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