Abstract
It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura–skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.
Original language | English |
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Pages (from-to) | 555-560 |
Number of pages | 6 |
Journal | Nature neuroscience |
Volume | 25 |
Issue number | 5 |
DOIs | |
State | Published - May 2022 |