TY - JOUR
T1 - Cerebrospinal Fluid Biomarkers of Pediatric Hydrocephalus
AU - Limbrick, David D.
AU - Castaneyra-Ruiz, Leandro
AU - Han, Roland H.
AU - Berger, Daniel
AU - McAllister, James P.
AU - Morales, Diego M.
N1 - Publisher Copyright:
© 2017 S. Karger AG, Basel.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Hydrocephalus (HC) is a common, debilitating neurological condition that requires urgent clinical decision-making. At present, neurosurgeons rely heavily on a patient's history, physical examination findings, neuroimaging, and clinical judgment to make the diagnosis of HC or treatment failure (e.g., shunt malfunction). Unfortunately, these tools, even in combination, do not eliminate subjectivity in clinical decisions. In order to improve the management of infants and children with HC, there is an urgent need for new biomarkers to complement currently available tools and enable clinicians to confidently establish the diagnosis of HC, assess therapeutic efficacy/treatment failure, and evaluate current and future developmental challenges, so that every child has access to the resources they need to optimize their outcome and quality of life.
AB - Hydrocephalus (HC) is a common, debilitating neurological condition that requires urgent clinical decision-making. At present, neurosurgeons rely heavily on a patient's history, physical examination findings, neuroimaging, and clinical judgment to make the diagnosis of HC or treatment failure (e.g., shunt malfunction). Unfortunately, these tools, even in combination, do not eliminate subjectivity in clinical decisions. In order to improve the management of infants and children with HC, there is an urgent need for new biomarkers to complement currently available tools and enable clinicians to confidently establish the diagnosis of HC, assess therapeutic efficacy/treatment failure, and evaluate current and future developmental challenges, so that every child has access to the resources they need to optimize their outcome and quality of life.
UR - http://www.scopus.com/inward/record.url?scp=85027127364&partnerID=8YFLogxK
U2 - 10.1159/000477175
DO - 10.1159/000477175
M3 - Review article
C2 - 28797007
AN - SCOPUS:85027127364
SN - 1016-2291
VL - 52
SP - 426
EP - 435
JO - Pediatric Neurosurgery
JF - Pediatric Neurosurgery
IS - 6
ER -