@article{b2716bb4873b45d798cffa95c9c95e7d,
title = "Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study",
abstract = "Introduction: One goal of the Longitudinal Early Onset Alzheimer's Disease Study (LEADS) is to define the fluid biomarker characteristics of early-onset Alzheimer's disease (EOAD). Methods: Cerebrospinal fluid (CSF) concentrations of Aβ1-40, Aβ1-42, total tau (tTau), pTau181, VILIP-1, SNAP-25, neurogranin (Ng), neurofilament light chain (NfL), and YKL-40 were measured by immunoassay in 165 LEADS participants. The associations of biomarker concentrations with diagnostic group and standard cognitive tests were evaluated. Results: Biomarkers were correlated with one another. Levels of CSF Aβ42/40, pTau181, tTau, SNAP-25, and Ng in EOAD differed significantly from cognitively normal and early-onset non-AD dementia; NfL, YKL-40, and VILIP-1 did not. Across groups, all biomarkers except SNAP-25 were correlated with cognition. Within the EOAD group, Aβ42/40, NfL, Ng, and SNAP-25 were correlated with at least one cognitive measure. Discussion: This study provides a comprehensive analysis of CSF biomarkers in sporadic EOAD that can inform EOAD clinical trial design.",
keywords = "Alzheimer's disease, Aβ42/40, CSF, NfL, SNAP-25, VILIP-1, YKL-40, amyloid, astrogliosis, biomarkers, dementia, neurogranin, pTau181, tTau, tau",
author = "Dage, {Jeffrey L.} and Ani Eloyan and Maryanne Thangarajah and Hammers, {Dustin B.} and Fagan, {Anne M.} and Gray, {Julia D.} and Schindler, {Suzanne E.} and Casey Snoddy and Nudelman, {Kelly N.H.} and Faber, {Kelley M.} and Tatiana Foroud and Paul Aisen and Percy Griffin and Grinberg, {Lea T.} and Leonardo Iaccarino and Kala Kirby and Joel Kramer and Robert Koeppe and Kukull, {Walter A.} and {La Joie}, Renaud and Mundada, {Nidhi S.} and Murray, {Melissa E.} and Malia Rumbaugh and Soleimani-Meigooni, {David N.} and Toga, {Arthur W.} and Alexandra Touroutoglou and Prashanthi Vemuri and Alireza Atri and Beckett, {Laurel A.} and Day, {Gregory S.} and Graff-Radford, {Neill R.} and Ranjan Duara and Honig, {Lawrence S.} and Jones, {David T.} and Masdeu, {Joseph C.} and Mendez, {Mario F.} and Erik Musiek and Onyike, {Chiadi U.} and Meghan Riddle and Emily Rogalski and Stephen Salloway and Sha, {Sharon J.} and Turner, {Raymond S.} and Wingo, {Thomas S.} and Wolk, {David A.} and Womack, {Kyle B.} and Carrillo, {Maria C.} and Dickerson, {Bradford C.} and Rabinovici, {Gil D.} and Apostolova, {Liana G.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",
year = "2023",
month = nov,
doi = "10.1002/alz.13399",
language = "English",
volume = "19",
pages = "S115--S125",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
number = "S9",
}