@article{39e325b330eb4954bd2ab36b3cf228b7,
title = "Cerebral glucose utilization in polysubstance abuse",
abstract = "Regional cerebral glucose metabolism in subjects with histories of polysubstance abuse was compared to that in control subjects who were drawn from the same community. The substance abuse group showed lower absolute metabolic rates for glucose in lateral occipital gyrus and higher normalized metabolic rates in temporal and frontal areas, including orbitofrontal cortex. It is suggested that some patterns of brain function associated with polysubstance abuse may represent consequences of drug exposure, or they could reflect pre-existing differences that may be relevant to the etiology and maintenance of polysubstance abuse.",
keywords = "Brain imaging, Cerebral glucose metabolism, Drug abuse, Fluorodeoxyglucose, Positron emission tomography, Substance abuse",
author = "Stapleton, {June M.} and Morgan, {Michael J.} and Phillips, {Robert L.} and Wong, {Dean F.} and Yung, {Babington C.K.} and Shaya, {Elias K.} and Dannals, {Robert F.} and Xiang Liu and Grayson, {Roger L.} and London, {Edythe D.}",
note = "Funding Information: The authors thank W. Robert Lange, M.D., and Carlo Con-toreggi, M.D., for medical coverage and Merrily Smith, R.N., and Robin Stauffer, R.N., for nursing services. Our appreciation is extended to Valerie O{\textquoteright}Brien, Jennifer Schmidt, and Loretta Spurgeon for assistance in data collection and analysis. We thank David Clough, C.N.M.T., for operation of the PET scanner and Stephen F. Gilson, Ph.D., for helpful discussions. The NIDA Intramural PET Research Program is supported by the Counterdrug Technology Assessment Center, Office of National Drug Control Policy, Office of the President.",
year = "1995",
month = aug,
doi = "10.1016/0893-133X(94)00132-J",
language = "English",
volume = "13",
pages = "21--31",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
number = "1",
}