Cerebral blood flow, oxygen utilization, and blood volume in dementia

Robert L. Grubb, Marcus E. Raichle, Mokhtar H. Gado, John O. Eichling, Charles P. Hughes

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Patients with dementia had significant decreases in cerebral blood flow and cerebral oxygen utilization and a mild, but not significant, increase in cerebral blood volume. These studies were not useful in distinguishing patients with cerebral atrophy from patients with normal pressure hydrocephalus, as similar changes in cerebral circulation and metabolism were seen in both groups. Changes in cerebral blood flow after acute decrease in the intracranial pressure also were not helpful in differentiating patients with normal pressure hydrocephalus from patients with cerebral atrophy.

Original languageEnglish
Pages (from-to)905-910
Number of pages6
Issue number10
StatePublished - Oct 1977


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