Cerebral Blood Flow, Measurement of

W. J. Powers, J. Markham

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Normal brain function requires adequate cerebral blood flow (CBF). Thus, understanding the physiology and pathophysiology of the brain requires accurate measurement of CBF. This article will describe the theory and practice of methods that have been used to measure CBF in both experimental animals and in humans, including the Fick Principle, the Central Volume Principle, the Compartmental Principle, and the use of radioactive and non radioactive tracers.

Original languageEnglish
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages4
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
StatePublished - Jan 1 2014


  • Autoradiography
  • Central volume principle
  • Cerebral blood flow
  • Compartmental models
  • Doppler
  • Fick Principle
  • Kety-Schmidt technique
  • Microsphere
  • Positron emission tomography (PET)
  • Single photon emission tomography (SPECT)
  • Xenon


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