Cerebral blood flow changes during vagus nerve stimulation for depression

Charles R. Conway; Yvette I. Sheline; John T. Chibnall; Mark S. George; James W. Fletcher; Mark A. Mintun

doi:10.1016/j.pscychresns.2005.12.007

Cerebral blood flow changes during vagus nerve stimulation for depression

Charles R. Conway, Yvette I. Sheline, John T. Chibnall, Mark S. George, James W. Fletcher, Mark A. Mintun

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

Positron emission tomography (PET oxygen-15 labeled water or PET [¹⁵O]H₂O) was used to identify changes in regional cerebral blood flow (rCBF) in response to acute vagus nerve stimulation (VNS) in four subjects with treatment-resistant major depression (TRMD). Four 90-s PET [¹⁵O]H₂O scans were performed on each subject in an off-on sequence (2 VNS de-activated; 2 VNS activated). PET images were aligned, normalized for global uptake, and resampled to standard atlas space. Statistical t-images were used to evaluate change. VNS-induced increases in rCBF were found in the bilateral orbitofrontal cortex, bilateral anterior cingulate cortex, and right superior and medial frontal cortex. Decreases were found in the bilateral temporal cortex and right parietal area. Regions of change were consistent with brain structures associated with depression and the afferent pathways of the vagus nerve.

Original language	English
Pages (from-to)	179-184
Number of pages	6
Journal	Psychiatry Research - Neuroimaging
Volume	146
Issue number	2
DOIs	https://doi.org/10.1016/j.pscychresns.2005.12.007
State	Published - Mar 31 2006

Keywords

Affective disorder
Positron emission tomography
Regional blood flow
Vagus nerve stimulation

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10.1016/j.pscychresns.2005.12.007

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title = "Cerebral blood flow changes during vagus nerve stimulation for depression",

abstract = "Positron emission tomography (PET oxygen-15 labeled water or PET [15O]H2O) was used to identify changes in regional cerebral blood flow (rCBF) in response to acute vagus nerve stimulation (VNS) in four subjects with treatment-resistant major depression (TRMD). Four 90-s PET [15O]H2O scans were performed on each subject in an off-on sequence (2 VNS de-activated; 2 VNS activated). PET images were aligned, normalized for global uptake, and resampled to standard atlas space. Statistical t-images were used to evaluate change. VNS-induced increases in rCBF were found in the bilateral orbitofrontal cortex, bilateral anterior cingulate cortex, and right superior and medial frontal cortex. Decreases were found in the bilateral temporal cortex and right parietal area. Regions of change were consistent with brain structures associated with depression and the afferent pathways of the vagus nerve.",

keywords = "Affective disorder, Positron emission tomography, Regional blood flow, Vagus nerve stimulation",

author = "Conway, {Charles R.} and Sheline, {Yvette I.} and Chibnall, {John T.} and George, {Mark S.} and Fletcher, {James W.} and Mintun, {Mark A.}",

note = "Funding Information: The authors thank Medhat Osman, Steve Farris, JoAnn Filla-Taylor, Vadim Baram, George Grossberg, and Avi Snyder for their invaluable assistance with this project. This work was supported by a grant from Cyberonics, Inc., Houston, Texas, USA (to C.R. Conway).",

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doi = "10.1016/j.pscychresns.2005.12.007",

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AU - Sheline, Yvette I.

AU - Chibnall, John T.

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AU - Fletcher, James W.

AU - Mintun, Mark A.

N1 - Funding Information: The authors thank Medhat Osman, Steve Farris, JoAnn Filla-Taylor, Vadim Baram, George Grossberg, and Avi Snyder for their invaluable assistance with this project. This work was supported by a grant from Cyberonics, Inc., Houston, Texas, USA (to C.R. Conway).

PY - 2006/3/31

Y1 - 2006/3/31

N2 - Positron emission tomography (PET oxygen-15 labeled water or PET [15O]H2O) was used to identify changes in regional cerebral blood flow (rCBF) in response to acute vagus nerve stimulation (VNS) in four subjects with treatment-resistant major depression (TRMD). Four 90-s PET [15O]H2O scans were performed on each subject in an off-on sequence (2 VNS de-activated; 2 VNS activated). PET images were aligned, normalized for global uptake, and resampled to standard atlas space. Statistical t-images were used to evaluate change. VNS-induced increases in rCBF were found in the bilateral orbitofrontal cortex, bilateral anterior cingulate cortex, and right superior and medial frontal cortex. Decreases were found in the bilateral temporal cortex and right parietal area. Regions of change were consistent with brain structures associated with depression and the afferent pathways of the vagus nerve.

AB - Positron emission tomography (PET oxygen-15 labeled water or PET [15O]H2O) was used to identify changes in regional cerebral blood flow (rCBF) in response to acute vagus nerve stimulation (VNS) in four subjects with treatment-resistant major depression (TRMD). Four 90-s PET [15O]H2O scans were performed on each subject in an off-on sequence (2 VNS de-activated; 2 VNS activated). PET images were aligned, normalized for global uptake, and resampled to standard atlas space. Statistical t-images were used to evaluate change. VNS-induced increases in rCBF were found in the bilateral orbitofrontal cortex, bilateral anterior cingulate cortex, and right superior and medial frontal cortex. Decreases were found in the bilateral temporal cortex and right parietal area. Regions of change were consistent with brain structures associated with depression and the afferent pathways of the vagus nerve.

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Cerebral blood flow changes during vagus nerve stimulation for depression

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