To date, regional measurements of cerebral blood flow in humans ave not been especially helpful in predicting the outcome of acute brain injury. The recent appearance within the medical environment of biologically significdnt pharmaceuticals labelled with the positron-emitting isotopes 15O, 13N and 11C has made possible the quantitative regional measurement of cerebral metabolism in humans. This advance, coupled with the development of radically new detection systems, will allow the safe measurement of truly regional blood flow and metabolism in humans in the near future. Such information is basic to an understanding of the pathophysiology of acute injury to the brain and the rational prediction of outcome in the individual case.
- Cerebral blood flow
- Human brain