@article{0747db478d3c43f7b46d3f2f15f95872,
title = "Central Vestibular Tuning Arises from Patterned Convergence of Otolith Afferents",
abstract = "Though computational models predict how sensory inputs converge in central neurons, it is technically challenging to test these ideas experimentally. With whole-cell recordings in larval zebrafish in vivo, Liu et al. demonstrate that the convergence of similarly or differently tuned vestibular afferents produces more simple or complex postsynaptic tuning, respectively.",
keywords = "body balance, electrical synapse, feedforward excitation, high-pass tuning, neural computation, sensorimotor transformation, sensory encoding, vestibulospinal neuron",
author = "Zhikai Liu and Yukiko Kimura and Higashijima, {Shin ichi} and Hildebrand, {David G.C.} and Morgan, {Joshua L.} and Bagnall, {Martha W.}",
note = "Funding Information: We are grateful to Dr. Timothy Holy for guidance on development of EPSC analysis and valuable feedback on the project. We thank Dr. Richard Roberts for helping set up the electrophysiology recording rig and Drs. Rebecca Callahan, Mohini Sengupta, and Mr. Saul Bello Rojas for thoughtful critiques of the paper. Drs. Daniel Kerschensteiner and David Schoppik also contributed insightful comments on the manuscript. We also acknowledge the Washington University Zebrafish Facility for fish care and Washington University Center for Cellular Imaging (WUCCI) for supporting the confocal imaging experiments. This work is supported by funding through the National Institutes of Health (NIH) R00 DC012536 (to M.W.B.), R56 DC016413 (to M.W.B.), R01 DC016413 (to M.W.B.), and R21EY030623 (to J.L.M.); a Sloan Research Fellowship (to M.W.B.); a Leon Levy Foundation Fellowship in Neuroscience (to D.G.C.H.); and the National BioResource Project in Japan (to S.H.). M.W.B. is a Pew Biomedical Scholar and a McKnight Foundation Scholar. J.L.M. is a recipient of a Research to Prevent Blindness Career Development Award . Funding Information: We are grateful to Dr. Timothy Holy for guidance on development of EPSC analysis and valuable feedback on the project. We thank Dr. Richard Roberts for helping set up the electrophysiology recording rig and Drs. Rebecca Callahan, Mohini Sengupta, and Mr. Saul Bello Rojas for thoughtful critiques of the paper. Drs. Daniel Kerschensteiner and David Schoppik also contributed insightful comments on the manuscript. We also acknowledge the Washington University Zebrafish Facility for fish care and Washington University Center for Cellular Imaging (WUCCI) for supporting the confocal imaging experiments. This work is supported by funding through the National Institutes of Health (NIH) R00 DC012536 (to M.W.B.), R56 DC016413 (to M.W.B.), R01 DC016413 (to M.W.B.), and R21EY030623 (to J.L.M.); a Sloan Research Fellowship (to M.W.B.); a Leon Levy Foundation Fellowship in Neuroscience (to D.G.C.H.); and the National BioResource Project in Japan (to S.H.). M.W.B. is a Pew Biomedical Scholar and a McKnight Foundation Scholar. J.L.M. is a recipient of a Research to Prevent Blindness Career Development Award. Y.K. and S.H. generated the Tg(nefma:gal4, UAS:GFP) fish line. Z.L. and M.W.B. conceived the project. Z.L. performed the electrophysiology and confocal imaging experiments and analyzed the data. M.W.B. J.L.M. and D.G.C.H. carried out the serial-section EM imaging and reconstruction. Z.L. and M.W.B. wrote the manuscript with input from all other authors. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = nov,
day = "25",
doi = "10.1016/j.neuron.2020.08.019",
language = "English",
volume = "108",
pages = "748--762.e4",
journal = "Neuron",
issn = "0896-6273",
number = "4",
}