Central role for CD40 / CD40 ligand (CD 154) interactions in transplant rejection

Mark D. Denton, Ross M. Reul, Vikas R. Dharnidharka, James C. Fang, Peter Ganz, David M. Briscoe

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Major advances have been made in understanding the expression and function of CD40 and its ligand CD154. It is now clear that CD40/ CD154 interactions are critical in many aspects of the immune response, including T cell activation, T cell-dependent macrophage activation, T cell-B cell interactions and endothelial activation. Moreover, increasing evidence supports a central role for CD40/ CD 154 interactions in the immune processes of allograft rejection. Functional studies using blocking monoclonal antibodies have revealed beneficial effects of interupting CD40/CD154 costimulation in animal models of transplantation, particularly in association with interuption of the CD28/B7 pathway. A next step is to develop new therapeutic approaches to interrupting this pathway in humans, either through the development of receptor antagonists or through the understanding of intracellular signaling pathways utilized by these molecules.

Original languageEnglish
Pages (from-to)6-15
Number of pages10
JournalPediatric transplantation
Issue number1
StatePublished - Dec 1 1998


  • Allograft rejection
  • C040/CD154 interaction


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