Central nervous system toxicities of chemotherapeutic agents

Parvin F. Peddi, Srinivas Peddi, Edgardo S. Santos, Daniel Morgensztern

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Although there has been a significant progress in the recognition and management of the most common chemotherapy side effects, there is limited data on CNS toxicities. Since CNS toxicities can cause significant morbidity and delay or interruption of potentially effective therapies, there is a need for better understanding, early detection, prompt discontinuation of the offending drug, and use of antidotes when available. This review describes neurological toxicities from some of the commonly used chemotherapy agents.

Original languageEnglish
Pages (from-to)857-863
Number of pages7
JournalExpert Review of Anticancer Therapy
Issue number7
StatePublished - Jul 2014


  • Antidotes
  • CNS
  • Chemotherapy
  • Encephalopathy
  • Posterior reversible encephalopathic syndrome


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