TY - JOUR
T1 - Central nervous system toxicities of chemotherapeutic agents
AU - Peddi, Parvin F.
AU - Peddi, Srinivas
AU - Santos, Edgardo S.
AU - Morgensztern, Daniel
PY - 2014/7
Y1 - 2014/7
N2 - Although there has been a significant progress in the recognition and management of the most common chemotherapy side effects, there is limited data on CNS toxicities. Since CNS toxicities can cause significant morbidity and delay or interruption of potentially effective therapies, there is a need for better understanding, early detection, prompt discontinuation of the offending drug, and use of antidotes when available. This review describes neurological toxicities from some of the commonly used chemotherapy agents.
AB - Although there has been a significant progress in the recognition and management of the most common chemotherapy side effects, there is limited data on CNS toxicities. Since CNS toxicities can cause significant morbidity and delay or interruption of potentially effective therapies, there is a need for better understanding, early detection, prompt discontinuation of the offending drug, and use of antidotes when available. This review describes neurological toxicities from some of the commonly used chemotherapy agents.
KW - Antidotes
KW - CNS
KW - Chemotherapy
KW - Encephalopathy
KW - Posterior reversible encephalopathic syndrome
UR - http://www.scopus.com/inward/record.url?scp=84903159669&partnerID=8YFLogxK
U2 - 10.1586/14737140.2014.911089
DO - 10.1586/14737140.2014.911089
M3 - Review article
C2 - 24745349
AN - SCOPUS:84903159669
SN - 1473-7140
VL - 14
SP - 857
EP - 863
JO - Expert Review of Anticancer Therapy
JF - Expert Review of Anticancer Therapy
IS - 7
ER -