@article{990eb4b8461140b1ae12f7fef6e2dba8,
title = "Central Nervous System Infections in the Immunocompromised Adult Presenting to the Emergency Department",
abstract = "Over the past 2 decades, the population of immunocompromised patients has increased dramatically in the United States. These patients are at elevated risk for both community-acquired and opportunistic central nervous system infections. We review the most common and serious central nervous system pathogens affecting these patients and outline a diagnostic and therapeutic approach to their management in the emergency department. We recommend a broad diagnostic evaluation, including neuroimaging and cerebrospinal fluid studies where appropriate, empiric antimicrobial therapy, and early involvement of subspecialists to provide comprehensive care for these complex patients.",
keywords = "CNS infection, HIV, Immunocompromise, Meningitis, Transplant",
author = "Stephens, {Robert J.} and Liang, {Stephen Y.}",
note = "Funding Information: R.J. Stephens and S.Y. Liang have no conflicts of interest to disclose. S.Y. Liang received support through the Foundation for Barnes-Jewish Hospital and the Washington University Institute of Clinical and Translational Sciences which is, in part, supported by the NIH/National Center for Advancing Translational Sciences (NCATS), Clinical and Translational Science Award (CTSA) program (UL1TR002345). Funding Information: R.J. Stephens and S.Y. Liang have no conflicts of interest to disclose. S.Y. Liang received support through the Foundation for Barnes-Jewish Hospital and the Washington University Institute of Clinical and Translational Sciences which is, in part, supported by the NIH / National Center for Advancing Translational Sciences (NCATS), Clinical and Translational Science Award (CTSA) program ( UL1TR002345 ). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = feb,
doi = "10.1016/j.emc.2020.09.006",
language = "English",
volume = "39",
pages = "101--121",
journal = "Emergency Medicine Clinics of North America",
issn = "0733-8627",
number = "1",
}