TY - JOUR
T1 - Central Nervous System
T2 - (Immunological) Ivory Tower or Not
AU - Marin, Ioana A.
AU - Kipnis, Jonathan
N1 - Publisher Copyright:
© 2017 American College of Neuropsychopharmacology.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The view of the nervous system being the victim of destructive inflammation during autoimmunity, degeneration, or injury has been rapidly changing. Recent studies are supporting the idea that the immune system provides support for the nervous system at various levels. Though cell patrolling through the nervous system parenchyma is limited compared with other tissues, immune cell presence within the central nervous system (CNS; microglia), as well as around it (in the meningeal spaces and choroid plexus) has been shown to be important for brain tissue maintenance and function. This review primarily explores recent findings concerning neuroimmune interactions and their mechanisms under homeostatic conditions.
AB - The view of the nervous system being the victim of destructive inflammation during autoimmunity, degeneration, or injury has been rapidly changing. Recent studies are supporting the idea that the immune system provides support for the nervous system at various levels. Though cell patrolling through the nervous system parenchyma is limited compared with other tissues, immune cell presence within the central nervous system (CNS; microglia), as well as around it (in the meningeal spaces and choroid plexus) has been shown to be important for brain tissue maintenance and function. This review primarily explores recent findings concerning neuroimmune interactions and their mechanisms under homeostatic conditions.
UR - http://www.scopus.com/inward/record.url?scp=84981163518&partnerID=8YFLogxK
U2 - 10.1038/npp.2016.122
DO - 10.1038/npp.2016.122
M3 - Review article
C2 - 27402496
AN - SCOPUS:84981163518
SN - 0893-133X
VL - 42
SP - 28
EP - 35
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 1
ER -