Central Nervous System: (Immunological) Ivory Tower or Not

Ioana A. Marin, Jonathan Kipnis

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

The view of the nervous system being the victim of destructive inflammation during autoimmunity, degeneration, or injury has been rapidly changing. Recent studies are supporting the idea that the immune system provides support for the nervous system at various levels. Though cell patrolling through the nervous system parenchyma is limited compared with other tissues, immune cell presence within the central nervous system (CNS; microglia), as well as around it (in the meningeal spaces and choroid plexus) has been shown to be important for brain tissue maintenance and function. This review primarily explores recent findings concerning neuroimmune interactions and their mechanisms under homeostatic conditions.

Original languageEnglish
Pages (from-to)28-35
Number of pages8
JournalNeuropsychopharmacology
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2017

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