Central Nervous System Complications After Transplantation

Rajat Dhar, Theresa Human

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

The incidence of serious neurologic complications after organ and stem cell transplantation can be as high as 20% to 30%, with most occurring in the early posttransplant period. Encephalopathy often results from metabolic disturbances and immunosuppressant drug neurotoxicity but can also occur with central pontine myelinolysis and other lesions of the central nervous system (CNS). Seizures are also common and can be related to drug toxicity or herald CNS disorders. A thorough evaluation of any patient who develops seizures or mental status changes after transplantation is warranted to distinguish transient reversible causes from serious CNS disorders.

Original languageEnglish
Pages (from-to)943-972
Number of pages30
JournalNeurologic Clinics
Volume29
Issue number4
DOIs
StatePublished - Nov 1 2011

Keywords

  • Bone marrow transplant
  • Brain diseases
  • Drug toxicity
  • Metabolic
  • Opportunistic infections
  • Organ transplantation
  • Seizures

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