Central CD4 + T cell tolerance: deletion versus regulatory T cell differentiation

Ludger Klein, Ellen A. Robey, Chyi Song Hsieh

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


The diversion of MHC class II-restricted thymocytes into the regulatory T (T reg ) cell lineage is driven by intrathymic encounter of agonist self-antigens in a similar manner to the clonal deletion of thymocytes. Somewhat paradoxically, it thus seems that the expression of an autoreactive T cell receptor is a shared characteristic of T cells that are subject to clonal deletion and T cells that are diverted into the T reg cell lineage. Here, we discuss how thymocyte-intrinsic and thymocyte-extrinsic determinants may specify the choice between these two fundamentally different T cell fates.

Original languageEnglish
Pages (from-to)7-18
Number of pages12
JournalNature Reviews Immunology
Issue number1
StatePublished - Jan 1 2019


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