TY - JOUR
T1 - Central CD4 + T cell tolerance
T2 - deletion versus regulatory T cell differentiation
AU - Klein, Ludger
AU - Robey, Ellen A.
AU - Hsieh, Chyi Song
N1 - Funding Information:
L.K. receives support from the European Research Council (ERC-2016-ADG 742290 - TOLERANCE FOOTPRINT) and the Deutsche Forschungsgemeinschaft (CRC 1054 ‘Control and plasticity of cell fate decisions in the immune system’). E.A.R. is supported by grants from the US National Institutes of Health (NIH AI064227 and AI065537). C.-S.H. is supported by the US National Institutes of Health (NIH AI079187 and AI131349).
Publisher Copyright:
© 2018, Springer Nature Limited.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The diversion of MHC class II-restricted thymocytes into the regulatory T (T reg ) cell lineage is driven by intrathymic encounter of agonist self-antigens in a similar manner to the clonal deletion of thymocytes. Somewhat paradoxically, it thus seems that the expression of an autoreactive T cell receptor is a shared characteristic of T cells that are subject to clonal deletion and T cells that are diverted into the T reg cell lineage. Here, we discuss how thymocyte-intrinsic and thymocyte-extrinsic determinants may specify the choice between these two fundamentally different T cell fates.
AB - The diversion of MHC class II-restricted thymocytes into the regulatory T (T reg ) cell lineage is driven by intrathymic encounter of agonist self-antigens in a similar manner to the clonal deletion of thymocytes. Somewhat paradoxically, it thus seems that the expression of an autoreactive T cell receptor is a shared characteristic of T cells that are subject to clonal deletion and T cells that are diverted into the T reg cell lineage. Here, we discuss how thymocyte-intrinsic and thymocyte-extrinsic determinants may specify the choice between these two fundamentally different T cell fates.
UR - http://www.scopus.com/inward/record.url?scp=85056457732&partnerID=8YFLogxK
U2 - 10.1038/s41577-018-0083-6
DO - 10.1038/s41577-018-0083-6
M3 - Review article
C2 - 30420705
AN - SCOPUS:85056457732
VL - 19
SP - 7
EP - 18
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
SN - 1474-1733
IS - 1
ER -