Cellular Therapies for Prolongation of Composite Tissue Allograft Transplantation

Justin M. Sacks, Elaine K. Horibe, W. P.Andrew Lee

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Complex musculoskeletal defects resulting from cancer, congenital absence, and trauma represent a unique reconstructive challenge. Autologous tissue is often unavailable to reconstruct these deformities. Composite tissue allograft transplantation represents a unique solution for these clinical problems. Face, hand, or limb transplants can be performed in a single procedure. However, the use of chronic nonspecific systemic immunosuppression can lead to side effects such as drug toxicity, opportunistic infections, and malignancies. This article explores various cell-based therapies that represent promising modalities to reduce chronic immunosuppression and alter the risk/benefit ratios for the prospect of composite tissue allograft transplantation.

Original languageEnglish
Pages (from-to)291-301
Number of pages11
JournalClinics in Plastic Surgery
Issue number2
StatePublished - Apr 2007


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