Cellular senescence, telomere recombination and maintenance

Q. Yang

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Cellular senescence can be activated by various types of stressful stimuli, including telomere shortening, oncogenic or tumor suppressor signals, and DNA damage. Progressive telomere shortening in successive cell divisions induces senescence due to the loss of terminal sequences during DNA replication. Maintenance of the telomere sequences at human chromosome ends is essential for immortalized cells to escape from the normal limitations of the proliferation capacity. In this article, the molecular and functional details of telomere maintenance and cellular senescence are reviewed, including the signals that trigger senescence, telomere capping, and the telomere length maintenance mechanisms.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalCytogenetic and Genome Research
Volume122
Issue number3-4
DOIs
StatePublished - Feb 1 2009

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