Cellular reprogramming: Chromatin puts on the brake

Piali Sengupta; Tim Schedl

doi:10.1016/j.cub.2010.12.044

Cellular reprogramming: Chromatin puts on the brake

Piali Sengupta, Tim Schedl

Research output: Contribution to journal › Short survey › peer-review

Abstract

Directed reprogramming of differentiated cells allows the generation of specific cell types for therapeutics and can provide unexpected insights into development. A recent study demonstrates that efficient reprogramming of Caenorhabditis elegans germ cells into neurons can be achieved by knocking down a histone chaperone gene and ectopic expression of a terminal selector transcription factor.

Original language	English
Pages (from-to)	R157-R159
Journal	Current Biology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.cub.2010.12.044
State	Published - Feb 22 2011

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title = "Cellular reprogramming: Chromatin puts on the brake",

abstract = "Directed reprogramming of differentiated cells allows the generation of specific cell types for therapeutics and can provide unexpected insights into development. A recent study demonstrates that efficient reprogramming of Caenorhabditis elegans germ cells into neurons can be achieved by knocking down a histone chaperone gene and ectopic expression of a terminal selector transcription factor.",

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AB - Directed reprogramming of differentiated cells allows the generation of specific cell types for therapeutics and can provide unexpected insights into development. A recent study demonstrates that efficient reprogramming of Caenorhabditis elegans germ cells into neurons can be achieved by knocking down a histone chaperone gene and ectopic expression of a terminal selector transcription factor.

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JO - Current Biology

JF - Current Biology

SN - 0960-9822

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Cellular reprogramming: Chromatin puts on the brake

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