@article{b43785945b0b41178a249d89f2311ac3,
title = "Cellular plasticity at the nexus of development and disease",
abstract = "In October 2020, the Keystone Symposia Global Health Series hosted a Keystone eSymposia entitled 'Tissue Plasticity: Preservation and Alteration of Cellular Identity'. The event synthesized groundbreaking research from unusually diverse fields of study, presented in various formats, including live and virtual talks, panel discussions and interactive e-poster sessions. The meeting focused on cell identity changes and plasticity in multiple tissues, species and developmental contexts, both in homeostasis and during injury. Here, we review the key themes of the meeting: (1) cell-extrinsic drivers of plasticity; (2) epigenomic regulation of cell plasticity; and (3) conservedmechanisms governing plasticity. A salient take-home conclusion was that there may be conservedmechanisms used by cells to execute plasticity,with autodegradative activity (autophagy and lysosomes) playing a crucial initial step in diverse organs and organisms.",
keywords = "Dedifferentiation, Metaplasia, Paligenosis, Reprogramming, Transdifferentiation",
author = "Spatz, {Lillian B.} and Jin, {Ramon U.} and Mills, {Jason C.}",
note = "Funding Information: The authors' research is funded by the National Heart, Lung, and Blood Institute (T32HL007088 to R.U.J.), and by the Barrett's Esophagus Translational Research Network (NCI U54CA163060 to R.U.J. and J.C.M.). L.B.S. thanks the Siteman Cancer Center Cancer Pathway Program (P30 CA091842 and T32CA113275). J.C.M. thanks the National Institute of Diabetes and Digestive and Kidney Diseases for support (P30 DK052574, R01DK105129, R01DK094989, R01DK105129, R01CA239645, R01CA246208 and R01DK110406). Funding Information: The authors{\textquoteright} research is funded by the National Heart, Lung, and Blood Institute (T32HL007088 to R.U.J.), and by the Barrett{\textquoteright}s Esophagus Translational Research Network (NCI U54CA163060 to R.U.J. and J.C.M.). L.B.S. thanks the Siteman Cancer Center Cancer Pathway Program (P30 CA091842 and T32CA113275). J.C.M. thanks the National Institute of Diabetes and Digestive and Kidney Diseases for support (P30 DK052574, R01DK105129, R01DK094989, R01DK105129, R01CA239645, R01CA246208 and R01DK110406). Publisher Copyright: {\textcopyright} 2021 Company of Biologists Ltd. All rights reserved.",
year = "2021",
month = feb,
doi = "10.1242/dev.197392",
language = "English",
volume = "148",
journal = "Development (Cambridge)",
issn = "0950-1991",
number = "3",
}