Cellular fatty acid uptake: a pathway under construction

Research output: Contribution to journalReview articlepeer-review

206 Scopus citations

Abstract

Membrane uptake of long-chain fatty acids (FAs) is the first step in cellular FA utilization and a point of metabolic regulation. CD36 facilitates a major fraction of FA uptake by key tissues. This review highlights the contribution of CD36 to pathophysiology in rodents and humans. Novel concepts regarding regulation of CD36-facilitated uptake are discussed (i.e. the role of membrane rafts and caveolae, CD36 recycling between intracellular depots and the membrane, and chemical modifications of the protein that impact its turnover and recruitment). Importantly, CD36 membrane levels and turnover are abnormal in diabetes, resulting in dysfunctional FA utilization. In addition, variants in the CD36 gene were shown recently to influence susceptibility for the metabolic syndrome, which greatly increases the risk of diabetes and heart disease.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume20
Issue number2
DOIs
StatePublished - Mar 2009

Fingerprint Dive into the research topics of 'Cellular fatty acid uptake: a pathway under construction'. Together they form a unique fingerprint.

Cite this