## Abstract

The importance of cellular dosimetry in both diagnostic and therapeutic nuclear medicine is becoming increasingly recognized. Methods: Experimental range-energy relations for electrons and alpha particles, along with derived geometric reduction factors, are used to calculate cellular absorbed fractions for these radiations. The resulting absorbed fractions are employed to calculate cellular S-values for several radionuclides. Results: Cellular absorbed fractions for monoenergetic electron sources with energies ranging from 0.1 keV to 1 MeV, distributed uniformly in the source region, are calculated for several target←source combinations including cell←cell, cell←cell surface, nucleus←nucleus, nucleus←cytoplasm and nucleus←cell surface. Similar data are also provided for monoenergetic alpha particle sources with energies ranging from 3 to 10 MeV. S-values are also conveniently tabulated for ^{32}P, ^{35}S, ^{86}Rb, ^{89}Sr, ^{90}Y, ^{91}Y, ^{114m}In, ^{131}I. Auger-electron-emitters ^{51}Cr, ^{67}Ga, ^{99m}Tc, ^{111}In, ^{123}I, ^{125}I, ^{201}Tl, ^{203}Pb and the alpha emitter ^{210}Po. In addition, S-values are given for radionuclides in the ^{212}Pb decay series, including ^{212}Pb, ^{212}Bi and ^{212}Po. Both absorbed fractions and S-values are supplied for a number of different size cells and cell nuclei. Conclusions: With the absorbed fractions and S-values in hand, along with experimentally determined information on the biokinetics and subcellular distribution of the radionuclides, the cellular self-absorbed dose can be conveniently calculated.

Original language | English |
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Pages (from-to) | 303-316 |

Number of pages | 14 |

Journal | Journal of Nuclear Medicine |

Volume | 35 |

Issue number | 2 |

State | Published - 1994 |

## Keywords

- S-values
- absorbed fractions
- alpha particles
- cellular dosimetry
- electrons